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Antimicrobial Activity of N-hexane and Ethyl Acetate Extracts of Erythrina Stricta Roxb

Mohammad Musarraf Hussain
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3802, Bangladesh

M Mizanur Rahman Mughal
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3802, Bangladesh

Md Masud Alam
Department of Microbiology, Noakhali Science and Technology University, Sonapur, Noakhali-3802, Bangladesh

Mohammad Golam Dastagir
Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

AHM Masum Billah
Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

M Ismail
Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

Abstract/ Executive Summary:

The crude n-hexane and ethyl acetate extract of the stem bark of E. stricta were subjected to microbiological investigation and were found to be significantly inhibitory to microbial growth, with the average zone of inhibition 12–17 and 10–16 mm, respectively. In the cytotoxic observation, the n-hexane and ethyl acetate extracts were found to show LC50 of 2.1 and 0.316 mg/ml respectively.

Keywords: Erythrina stricta, Fabaceae, Antimicrobial activities and Cytotoxicity observation

Location: Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3802

Start Date: 00-00-2008

End Date: 00-00-2008

Program Area: Development of Host and Medicinal Plants

Commodity: Diseases

Objectives:

To study Antimicrobial activity of n-hexane and Ethyl acetate extracts of Erythrina stricta Roxb.

Methodology:

Plant material - Plant sample of Erythrina stricta was collected from Brahramanbaria in April 2008. A voucher specimen has been deposited in University of Dhaka Herbarium (Herbarium No : 20250). The stem bark of this plant usually collected in fresh condition Therefore it should be washed well. It was cut in small pieces and then sun dried followed oven dried at reduced temperature (25⁰c) and powdered after drying. Antimicrobial Screening - Antimicrobial screening performed according to published principle of single-disk method1. Standard antibiotic (kanamycin) discs and blank discs were used as positive and negative control. The antimicrobial activity of the test agent was then determined by measuring the diameter of zone of inhibition expressed in millimetre1,2,10. The crude extracts (n–hexane and ethyl acetate) were tested for antimicrobial activity by disc diffusion method.

Source of Information: Bangladesh J Microbiol, Volume 27, Number 2, December 2010, pp 65-66

Article Link (Online Journal):

Funding Source:

Budget:

Total Budget (Tk.) :

Achievement/Findings:

The average zones of inhibition produced by n–hexane and ethyl acetate extract were found to be 12-17 mm and 10-16 mm, respectively at a concentration of 400 mg/disc.

Knowledge Management: Journal