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Infiltrating Ductal Carcinoma of Mammary Gland in a German Shepherd Dog

R. Sharmin
Intern Student
Department of Medicine and Surgery, Chittagong Government Veterinary College, Puhartali, Chillagong-4202, Bangladesh.

M. M. Rahman
Department of Medicine and Surgery, Chittagong Government Veterinary College, Puhartali, Chillagong-4202, Bangladesh.

M. Masuduzzaman
Department of Pathology, Chittagong Government Veterinary College, Puhartali, Chillagong-4202, Bangladesh.

Abstract/ Executive Summary:

A German Shepherd bitch of about 2.5 years old showed swollen ulcerated L-5 mammary gland. The affected L-5 gland and adjacent Iymphnode were excised and processed for histological study with routine Hematoxylin and Eosin staining method. The ductular epithelial cells showedd polymorphism and adenoid pattern growth of cells with hyperchromatric nuclei. Metastasis was not evident in the excised lymphnode. The neoplastic epithelial cells infiltered the surround tissue. On the basis of histopathological finding this case was diagnosed as infiltering ductal carcinoma.

Keywords: Ductal carcinoma, Mammary gland, German Shepherd, Dog

Location: Chittagong Government Veterinary College

Start Date:

End Date:

Program Area: Animal Health and Management

Commodity: Animal

Objectives:

To study the surgical removal and histopathology of the mammary tumor of a dog.

Methodology:

The German Shepherd bitch of about 2.5 years old was admitted in the Teaching Veterinary Hospital, Chittagong Government Veterinary College, suffering from swollen ulcerated mammary gland. Concurrent clinical signs were dullness, depression and inappetence and slightly elevated temperature. Previously the bitch was treated by field veterinarian suspecting mastitis. The swollen mammary gland (left-5) was pendunculated and ulcerated with hard in consistency. Left-4 mammary gland was also little bit swollen. Decision was taken for surgical removal of the affected glands. The animal was fasted for 12 hours before operation. The surgical site was prepared aseptically. It was premedicated with chlorpromazine @ 0.4 mg/kg body weight (Largactil, Aventis, Bangladesh Ltd.) and diazepam @ 0.4 mg/kg body weight (Sedil, Square, Bangladesh Ltd.). After 15 minutes thiopenton- sodium @ 20 mg/kg (Pentothal, Abott Laboratories India Ltd.) was used for anaesthesia. An elliptical incision was made around the L-5^th mammary gland (a minimum of 1cm from the tumor). The incision was continued through subcutaneous tissue to the fascia of the external abdominal wall. Precaution was taken to avoid incising mammary tissue. Traction on the elevated skin section was made to facilitate dissection. The inguinal rat pad and lymphnode were separated from the mammary gland. Continuing gliding scissors dissection was reached up to caudal superficial epigastric vessels. After ligating the epigastric vessels, the mammary gland was excised. The L - 4 mammary gland was excised in the same way by ligating craniosuperficial vessels. A lymphnode adjacent to the L - 5 mammary gland was excised for histopathology. The wound was luvaged with normal saline and evaluated whether any abnormal tissue remained. The skin edges were brought closer by suturing the muscle layer. The skinedges were apposed by horizontal mattress suture using silk. A tissue sample from the swollen mammary gland was preserved in 10% formalin. After processing and sectioning. the histological sections were stained with hematoxylin and cosin following the routine procedures.

Source of Information: Bangl. J. Vet. Med. (2005). 3 (2): 174-176

Article Link (Online Journal): http://dx.doi.org/10.3329/bjvm.v3i2.11403

Funding Source:

Budget:

Total Budget (Tk.) :

Achievement/Findings:

The ductular epithelial cells showedd polymorphism and adenoid pattern growth of cells with hyperchromatric nuclei. Metastasis was not evident in the excised lymphnode. The neoplastic epithelial cells infiltered the surround tissue. On the basis of histopathological finding this case was diagnosed as infiltering ductal carcinoma.It may be concluded that infiltrating ductal carcinomas were more fatal than adenocarcinomas and had a higher rate of metastasis. But the dog survived as there was no metastasis and the operation was done in time.

Knowledge Management: Journal