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Research Detail

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M. S. Islam
Department of Medicine, Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh & Upazila Livestock Office,Tala, Satkhira

M. M. Rahman
Community-based Dairy Veterinary Foundation, Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh

M. M. U. Bhuiyan
Community-based Dairy Veterinary Foundation, Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh

M. Shamsuddin
Community-based Dairy Veterinary Foundation, Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh

M. T. Islam
Department of Medicine, Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh & International Atomic Energy Agency, Austria, Vienna

A single blind clinical trial was carried out in Satkhira district where dairy operations by Community-based Dairy Veterinary Foundation,Bangladesh Agricultural University, Mymensingh were running. A total of 80 cattle and goats affected with different bacterial diseases were used for treatment with oxytetracycline, amoxicillin, combined preparation of sulfamethoxazole and trimethoprim, and tylosin. Diagnosis of diseases was based on clinical history and signs. Haemorrhagic septicemia (HS) affected cattle aged between 3 and 6 were treated with oxytetracycline (Tetravet-100, Acme, Bangladesh; DUFA-OTC 20% LA, DutchFarm,Holland). Amoxicillin (Amoxicillin trihydrate, Jickstar Pharma Inc.,Philippines; Moxilin Vet LA, The ACME Laboratories Ltd.,Bangladesh) was used in the treatment of calf pneumonia. Foot rot in cows, arthritis in calf and goat were treated with sulphamethoxazole and trimethoprim (Politrim-Vet, The ACME Laboratories Ltd.,Bangladesh). Bronchopneumonia in non-lactating cows and goats were treated with tylosin (Tylovet (Acme). The efficacy of oxytetracycline, amoxicillin, sulfamethoxazole and trimethoprim, and tylosin for the treatment of haemorrhagic septicemia, calf pneumonia, foot rot and bronchopneumonia were evaluated on the basis of recovery rate. Treatment of haemorrhagic septicemia with both antibiotics showed 100% recovery rate. The duration of complete recovery in Tetravet-100 treated group was 4-6 days with median of 5 days. In the DUFA-OTC 20% LA treated group it was 3-5 days with median of 4 days. Moxilin Vet (Acme) and Amoxicillin trihydrate (Jickstar Pharma) were evaluated against calf pneumonia in cattle. Cent percent cattle were cured with both the antibiotics, Moxilin Vet (Acme) and Amoxicillin trihydrate (Jickstar Pharma). For both antibiotics, the median days of complete recovery was 5. Of 5 foot rot affected cows treated with a combined preparation of sulfamethoxazole and trimethoprim (Politrim-Vet, Acme), 4 (80%) recovered within 4-5 days of treatment. However, treatment of arthritis affected calf and goat with same preparation showed 90% and 100% recovery rate, respectively. Treatment of bronchopneumonia cases with tylosin (Tylovet, Acme) resulted in 80% recovery in non-lactating cows and 90% in goats and it took 4-5 days for recovery with a median of 4 days.

  Haemorrhagic septicemia, Pneumonia, Arthritis, Foot rot, Oxytetracycline, Amoxicillin, Cattle, Goats
  Community-based Dairy Veterinary Foundation, Satkhira district
  00-09-2011
  00-08-2012
  Animal Health and Management
  Diseases, Goat, Cattle

To treat a number of bacterial diseases in cattle and goats at field setting based on presumptive diagnosis.

A single blind clinical trial was carried out for a period of one year, from September 2011 to August 2012 in Satkhira district where dairy operations by Community-based Dairy Veterinary Foundation, Bangladesh Agricultural University, Mymensingh were running. A total of 80 cattle and goats affected with different bacterial diseases were used for treatment with oxytetracycline, amoxicillin, combined preparation of sulfamethoxazole and trimethoprim and tylosin. Drugs used- Amoxicillin trihydrate: Amoxicillin trihydrate (150mg/ml), 100 ml vial, Jickstar Pharma Inc., Philippines, Moxilin Vet LA (150mg/ml), The ACME Laboratories Ltd., Bangladesh; Oxytetracycline hydrochloride: Tetravet-100 (100mg/ml), 10 ml vial, The ACME Laboratories Ltd., Bangladesh, DUFA-OTC 20% LA (200mg/ml), 100 ml vial, Dutch Farm, Holland; Sulphamethoxazole and Trimethoprim: Politrim-Vet (Sulphamethoxazole 200mg and Trimethoprim 40mg/ml), 100 ml vial, The ACME Laboratories Ltd., Bangladesh; Tylosin: Tylovet (200mg/ml), 10 ml vial, The ACME Laboratories Ltd., Dhaka, Bangladesh. Presumptive diagnosis of diseases- The haemorrhagic septicemia was diagnosed on the basis of clinical signs, which included high temperature, salivation, swelling of the throat and difficulty in breathing. The clinical cases with increased respiratory rate, respiratory distress with abnormal lung sounds, fever, serous nasal discharge and at the most mild depression or inappetence were diagnosed as calf pneumonia/bronchopneumonia. Foot rot was typically diagnosed by the distinctive lesions and odor. Any interdigital fissures and cracks with a characteristic odor was treated as foot rot. Arthritis was diagnosed by swollen joint which were painful and warm to touch and lameness of varying degrees of severity. Treatment protocol- Haemorrhagic septicemia affected cattle- Twenty affected cattle aged between 3 and 6 years were systematically selected, of which ten were treated with Tetravet-100 (Acme, Bangladesh) @ 1 ml/10 kg body weight IM once daily for 5 days while other ten received two doses of DUFA-OTC 20% LA (DutchFarm, Holland) @ 1 ml/10 kg body weight IM at 48 hours interval. In addition, all the cattle received ketoprofen (Keto-A Vet, Acme) @ 3 ml/100 kg body weight IM once daily for 3 days. Calf pneumonia- Twenty affected calf aged between 4 and 10 months, were systematically selected, of which ten received two doses of Moxilin Vet LA (Acme) @ 1 ml/10 kg body weight IM at 48 hours interval while other ten were treated with Amoxicillin trihydrate (Jickstar Pharma, Inc., Philippines) @ 1 ml/15 kg body weight IM once daily for 5 days. In addition, all the calves received chlorpheniramine maleate (Asta Vet, Acme) @ 1 ml/25 kg body weight IM once daily for 5 days. Foot rot in cows, arthritis in calf and goat- A total of 5 foot rot affected cows of 4-5 years old, and 10 arthritis affected calves (10-12 months old) were treated with Politrim-Vet (Acme) @ 1 ml/15 kg body weight IM once daily for 5 days. Five goats affected with arthritis were also treated with Politrim-Vet @ 1 ml/10 kg body weight IM once daily for 5 days. In addition, all the cattle and goats received ketoprofen (Keto-A Vet, Acme) @ 3 ml/100 kg body weight IM once daily for 3 days. Bronchopneumonia in non-lactating cows and goats - Ten non-lactating cows and ten goats affected with bronchopneumonia were treated with Tylovet (Acme) @ 1ml/10 kg body weight once daily for 5 days. In addition, all the cows and goats received chlorpheniramine maleate (Asta Vet, Acme) @ 1 ml/25 kg body weight IM once daily for 5 days.

  Bangl. J. Vet. Med. (2016). 14 (1): 47-51
  DOI: https://doi.org/10.3329/bjvm.v14i1.28822
Funding Source:
1.   Budget:  
  

In case of arthritis and foot rot treatment, several antimicrobials have been reported to be effective like potentiated sulfonamides, oxytetracycline, and ceftiofur. Among them the efficacy level of potentiated sulfonamides and ceftiofur is high, which supports the present finding in which 80-100% efficacy was found with the treatment of potentiated sulfonamides (Politrim-Vet, Acme) in the treatment of foot rot and arthritis. Tylosin, an antibiotic of the macrolide class, is indicated in the treatment of a wide range of diseases in cattle and goats caused by Gram-positive organisms and a limited range of Gram-negative organisms. Here, in this study the efficacy of tylosin (Tylovet, Acme) in the treatment of bronchopneumonia in non- lactating cows and goats was 80-90%

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