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Research Detail

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Dr Shammin Haque
Assistant Professor
Department of Pharmacology, Sir Salimullah Medical College and Mitford Hospital, Dhaka.

Dr Ferdous Ara
Professor
Department of Pharmacology, Sir Salimull Medical College and Mitford Hospital, Dhaka.

Dr Md Jalaluddin Iqbal
Associate Professor
Department of Pharmacology, Sir Salimull Medical College and Mitford Hospital, Dhaka.

Sheikh Nazrul Islam
Professor
Institute of Nutrition and Food Science University of Dhaka, Dhaka.

This study was conducted to evaluate the effect of dierent extracts of Aloe Vera gel in alloxan induced hyperglycaemic mice. Three dierent extracts of Aloe Vera gel (dried extract, ethanolic extract and fresh raw extract) were orally administered at 300 mg/kg body weight for 28 days. The fasting blood glucose level was estimated both in normal and alloxan induced hyperglycaemic mice. It was found that, when compared with the control, there was a signicant reduction in blood glucose level in all three experimental groups. Ethanolic and fresh raw gel extracts were more eective than the dried extract. The extracts produced similar results when compared with gliclazide. It can be concluded that, the administration of Aloe Vera gel extract signicantly decreases blood glucose level in hyperglycaemic mice. Aloe Vera gel can therefore be a natural remedy and a cost eective resource for the management of diabetes.

  Aloe Vera gel, Alloxan induced mice, Blood glucose level, Diabetes
  Department of Pharmacology and Therapeutics of Sir Salimullah Medical College in collaboration with the Institute of Nutrition and Food Science (INFS), University of Dhaka.
  
  
  Development of Host and Medicinal Plants
  Aloe Vera

To investigate the effect of the dierent extracts of Aloe Vera gel on blood glucose level of normal and experimentally induced hyperglycaemic mice.

The study was carried out in the Department of Pharmacology and Therapeutics of Sir Salimullah Medical College in collaboration with the Institute of Nutrition and Food Science (INFS), University of Dhaka. 42 healthy Swiss albino mice were purchased from the animal resource division of International Centre for Diarrhoeal Disease and Research, Bangladesh (ICDDR, B), Mohakhali, Dhaka. They were of 8 to 10 weeks old, of both sex and weighing between 30 to 40 grams. They were housed in clean metallic cages individually in a well ventilated room within room temperature of about 26°C -28°C in the animal house of the Institute of Nutrition and Food Science, Dhaka University, Dhaka. The animal house was maintained under a constant light and dark cycle alternating every 12 hours. The mice were allowed to feed upon standard food pellets and drink water ad libitum, except for the overnight fast, the day before blood glucose estimation. During fasting, they were allowed free access to water only. Alloxan monohydrate was purchased from Loba chemicals, India. Gliclazide as Dimerol of Drug International Pvt Ltd was used as positive control. Fresh Aloe Vera leaves were bought from a local market in Old Dhaka. The animal experiment comprised of experiment I and experiment II. Diabetes was not induced in the mice of experiment I. Alloxan (150mg/kg) was injected to induce diabetes in animals of experiment II. Experiment – I : This part of experiment was carried out to observe the eect of fresh raw Aloe Vera gel on blood glucose level in normal fasting mice. 12 mice were divided into 2 groups, group A and group B, each comprising 6 mice. All mice were fasted overnight before collection of blood to determine the fasting blood glucose level. Group-A (Non-diabetic control): Mice were given standard mice feed and water for 28 days. Fasting blood glucose level was estimated on day 1 and day 29 of the experiment. Group-B (Non-diabetic + Aloe vera control): Mice were given fresh raw Aloe Vera gel (300mg/kg) orally along with mice pellets and water for 28 days. Fasting blood glucose level was estimated on day 1 and day 29 of the experiment. Experiment – II: This part of study was carried out to see the eect of dierent extracts of Aloe Vera gel on blood glucose level in alloxan induced hyperglycaemic mice. The glucose lowering eect of the extract was compared with a standard oral antidiabetic drug, Gliclazide. A total of 32 mice were divided into ve groups, each comprising 6 mice. All animals were made diabetic by intraperitoneal administration of alloxan at 150 mg/kg body weight. Group-C (Diabetic control group-negative control): Mice received standard food and water. Fasting blood glucose level was estimated on day 1 (before alloxan injection), on day 4 (after alloxan to conrm diabetes induction) and on day 29 of the experiment. Group D (Experimental group): is group was divided into group D1, D2 and D3 from day 4 of the experiment (after conrming diabetes). Group D1 - mice were fed with dried extract of Aloe Vera gel (300mg/kg) orally by means of micropipette along with standard food and water for 28 days. Group D2 - mice were fed with ethanolic extract of Aloe vera gel (300mg/kg) orally by means of micropipette along with standard food and water for 28 days. Group D3 - mice were fed with fresh raw Aloe vera gel (300mg/kg) orally by means of micropipette along with standard food and water for 28 days. Fasting blood glucose level was estimated on day 1 (before alloxan), day 4 (after alloxan) and day 29 of the experiment of all 3 sub groups. Group E (Anti-diabetic drug group-positive control): Gliclazide (50mg/kg) was given orally along with standard food for 28 days from day 4 onwards. Fasting blood glucose level was estimated on day 1(before alloxan), day 4 (after alloxan) and day 29 of the experiment. After 28 days of treatment, mice blood sample was collected from the tail vein by tail tipping for the estimation of fasting blood glucose level. All the animals were then sacriced under light chloroform anesthesia after completion of treatment on day 29. Blood was obtained in eppendorf tubes and centrifuged at 5000 rpm for 15 minutes for the separation of serum. is serum was then used for biochemical analysis. Determination of serum glucose concentration was done by oxidase and peroxidase (GOD-POD) method using glucose estimation kit (Human, Germany) and microtiter plate reader (Multiskan EX , Labsystems, Finland). The results are given as mean and standard deviation for the independently performed experiments. Unpaired students’t test was used to see the level of signicance. A ‘p’ value of <0.05 was considered as statistically signicant. e study protocol was approved by the institutional ethical committee.

  Bangladesh Med J. 2015 May; 44 (2)
  
Funding Source:
1.   Budget:  
  

The present results suggested that the extracts of Aloe Vera gel are euglycaemic, which might be a useful blood glucose lowering agent for the treatment of diabetes mellitus. Fresh raw Aloe Vera gel may be a cheap and effective option to manage diabetes mellitus, especially in developing nations. If these experimental data are endorsed in clinical trials in future, Aloe Vera gel extract may emerge as a natural source to offer an alternate or adjuvant remedy for type 2 diabetes.

  Journal
  


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