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Comparative Efficacy of Piperazine Citrate, Levamisole and Pineapple Leaves Extract Against Naturally Infected Ascariasis in Indigenous Chickens

M. E. Hoque
Postgraduate student
Department of Pharmacology, BAU, Mymensignh

M. Mostofa
Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh

M .A. Awal
Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh

M. E. Choudhury
Department of Pharmacology, Faculty of Veterinary Science, Bangladesh agricultural University, Mymensingh-2202, Bangladesh

M. A. Hossain
Postgraduate student, Department of Pharmacology, BAU, Mymensignh

M. A. Alam
Postgraduate student
Department of Pharmacology, BAU, Mymensignh

Abstract/ Executive Summary:

The experiment was carried out to determine the comparative efficacy of piperazine citrate, levamisole and pineapple leaves extract as anthelmintics against ascariasis in chicken in the Department of Pharmacology in collaboration with Department of Parasitology, Bangladesh Agricultural University, Mymensingh, Bangladesh, during the period from July to October 2004. Accordingly forty chickens naturally infected with ascarid parasite were selected for this experiment. The chickens were equally divided into 4 (A, B, C and D) groups. Group A was kept as infected control, while groups B, C and D were treated with piperazine citrate, levamisole and pineapple leaves extract, respectively. Although pineapple leaves extract showed less effectiveness in reducing parasite count in postmortem examination than piperazine citrate and levamisole but its use may be encouraging because of less adverse effects. In all treated groups total erythrocyte count (TEC), hemoglobin estimation (Hb) and packed cell volume (PCV) significantly (p< 0.01) increased and erythrocyte sedimentation rate (ESR) and total leukocyte count (TLC) significantly (p < 0.01) decreased. Body weight was found to be increased following administration of piperazine citrate, levamisole and pineapple leaves extract.

Keywords: Piperazine citrate, Levamisole, Pineapple leaves, Ascariasis, Chicken

Location: Department of Pharmacology in collaboration with Department of Parasitology, Bangladesh Agricultural University, Mymensingh

Start Date: 00-07-2004

End Date: 00-10-2004

Program Area: Development of Host and Medicinal Plants

Non-commodity: Performance

Objectives:

The present research work was conducted to evaluate the comparative efficacy of modern anthelmintics such as piperazine citrate, levamisole and indigenous plant pineapple leaves extracts for the treatment ascariasis in chickens.

Methodology:

The experiment was conducted in the Department of Pharmacology in collaboration with Department of Parasitology, Bangladesh Agricultural University, Mymensingh, during the period from July to October 2004. A total of 40 indigenous chickens infected with ascarid parasites were purchased from the surrounding village to study the comparative efficacy of some patient anthelmintics and pineapple leaves extract against ascariasis. The chickens were weighed between 200 to 300 g and aged between 60 to 90 days and were selected on the basis of faecal examination. The infected chicken of grouped into A, B, C and D, each consisting of ten. Chicken of groups B, C and D were treated orally with single dose of piperazine citrate @ 200 mg/kg body weight, levamisole @ 20 mg/kg body weight and pineapple leaves extract @ 1 g /kg body weight, respectively, while chickens of group A kept as control. One chicken from each group was subjected to sacrifice before commencement of treatment and weekly after up to 28 days of observation to count the number of ascarid parasites as well as to observe any pathological changes present in tissues. Similarly, weekly recording of average body weight and collection of blood samples from wing vein with anticoagulant were performed from randomly selected five chickens of each group before and after treatment up to 28 days of observation. Haematological parameters such as total erythrocyte count (TEC), haemoglobin (Hb), packed cell volume (PCV), erythrocyte sedimentation rate and total leukocyte count (TLC) were determined following methology of Coffin (1955). The data were analyzed for significant variation between control and treated groups by repeated measures of analysis of variance.

Source of Information: Bangl. J. Vet. Med. (2006). 4 (1): 27–29

Article Link (Online Journal):

Funding Source:

Total Budget (Tk.) :

Achievement/Findings:

No parasites were recorded on 7th day following treatment with levamisole and on 14th day after treatment with piperazine citrate. Similar findings have been reported by Pavlick and Dykova. (1975). Pineapple leaves evacuated cent percent parasites on 28th day following treatment. On the 28th day after treatment, one chicken from each group was slaughtered to observe the adverse effects of those drugs on internal organs of treated chicken, but there were no any significant pathological lesions found.

Knowledge Management: Journal