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Comparative Efficacy of the Selected Indigenous Medicinal Plants with a Patent Drug Levamisole Against Ascariasis in Village Poultry

R. R. Sarker
Department of Pharmacology, Bangladesh Agricultural University, Mymensingh

M. Mostofa
Department of Pharmacology, Bangladesh Agricultural University, Mymensingh

M. A. Awal
Department of Pharmacology, Bangladesh Agricultural University, Mymensingh

M. S. Islam
Department of Medicine, Surgery and Obstetrics, Hajee Mohammad Danesh Science and Technology University, Basherhat, Dinajpur

R. Mian
Department of Pharmacology, Bangladesh Agricultural University, Mymensingh

Abstract/ Executive Summary:

The experiment was conducted at the Department of Pharmacology, Bangladesh Agricultural University, Mymensingh, during the period from July 2005 to November 2006 to study the comparative efficacy of indigenous medicinal plants Neem (Azadirachta indica) and Bothua (Chenopodium album) with a patent drug Levamisole (Poulnex) against Ascariasis. Sixty ascarid infected chickens were randomly divided into 6 equal groups and treatment schedule were as follows: Group A = Controlled (Infected), Group B = Levamisole 30mg/kg b. wt; Group C = Neem 1gm/kg b. wt. (Alcoholic extract); Group D = Neem 1gm/kg b. wt. (crude extract); Group E = Bothua 1gm/kg body wt. (Alcoholic extract) Group F = Bothua 1gm/kg body wt. (Crude extract) orally once at a time and closely observed for 28 days. Fecal egg count (EPG) were 100% reduced in Levamisole and Neem (alcoholic and water extract) treated groups. On the other hand EPG were somewhat increased in other three groups. Body weight TEC, Hb and PCV were increased significantly in above mentioned three groups (Levamisole and both groups of Neem) and decreased in rest three groups but TLC and ESR were decreased significantly. After post mortem examination no parasites were found in three groups of treated poultry (Levamisole and both groups of Neem). Parasites were remained available (17-24 numbers) in rest three groups. So it is concluded that Neem (Azadirachta indica) and levamisole is equally effective but Bothua (Chenopodium album) is completely ineffective against Ascariasis in village poultry.

Keywords: Efficacy, Medicinal plant, Ascariasis, Poultry

Location: Mymensingh,

Start Date: 01-07-2005

End Date: 30-11-2006

Program Area: Animal Health and Management

Commodity:

Objectives:

To study the comparative study of Neem (Azadirachta indica) and Bathua (Chenopodium album) extract with that of patent drug (Poulnex) levamisole in village poultry.

Methodology:

The experiment was conducted at the Department of Pharmacology, Bangladesh Agricultural University, Mymensingh, during the period from July 2005 to November 2006. To complete the research work following steps were followed. One hundred village poultry were purchased from the local market of Mymensingh out of which 60 Ascarid positive birds were selected to study the comparative efficacy of the selected indigenous plants Neem (Azadiracta indicia) and Bathua (Chenopodium album) with a patent drug Poulnex (Levamisole) against Ascariasis in village poultry. The chickens were allowed to take rest for 7 days for the adaptation. The experiment was carried out in poultry shed of the Department of Pharmacology, Bangladesh Agricultural University, Mymensingh. The age and body weight of all selected chicken ranged from 2 to 4 months and 345 to 405gm respectively. The chickens were supplied with normal diet and drinking water. Neem (Azadiracta indica) leaves were collected from the garden of medicinal plants of the Department of Pharmacology, BAU. Lamber`s quarter (Chenopodium album) plants were collected from the K.R Market of BAU. All the 60 Ascaris infected chickens were randomly divided into 6 groups (A, B, C, D, E & F), each group consisting of 10 village poultry. Group A = Controlled (Infected); Group B = Treated with Levamisole 30mg/kg body wt., Group C = Treated with Neem (Alcoholic extract) 1gm/kg body wt; Group D = Treated with Neem (crude extract) 1gm/kg body wt.; Group E = Treated with Lamber`s quarter (Alcoholic extract) 1gm/kg body wt.; Group F = Treated with Lamber`s quarter (Crude extract) 1gm/kg body wt. The data were analyzed statistically between control and treated groups of fowls by the well known student’s test (‘t’ test).

Source of Information: Bangl. J. Vet. Med. (2009). 7(2) : 320 – 324

Article Link (Online Journal):

Funding Source:

Total Budget (Tk.) :

Achievement/Findings:

From this trial, it is concluded that among Poulnex Neem and Chinopodium, Poulnex and neem are more effective against Ascariasis in village poultry. But Poulnex is not cost-effective and not easily available for rural people; From this sense Neem is considering more suitable one. Indeed this study is preliminary one considering small population and however, further research works should be carried out to explore the possible therapeutic issue of Neem against Ascariasis in village poultry.

Knowledge Management: Journal