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Comparative Efficacy of Some Modern Anthelmintics and Pineapple Leaves with Their Effects on Certain Blood Parameters and Body Weight Gain in Calves Infected with Ascarid Parasites

S. A. Islam
Department of Pharmacology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

M. M. Rahman
Department of Pathology and Parasitology. Chittagong Government Veterinary College, Pahartali, Chittagong-4202, Bangladesh.

M.A. Hossain
Department of Pathology and Parasitology. Chittagong Government Veterinary College, Pahartali, Chittagong-4202, Bangladesh.

M.G. A. Chowdhury
Veterinary Surgeon, Directorate of Livestock Services, Bangladesh

M. Mostafa
Department of Pharmacology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

Abstract/ Executive Summary:

A twenty five calves of naturally infected with ascarid parasites were treated with different modern anthelmintics and pineapple leaves to study the comparative efficacy during the period from January to September I m.The calves were divided into five groups. Groups A, B, C, D were treated with ivermectin (200 1-1g 1 kg SC), albendazole (7.5 mg 1 kg orally), piperazine citrate (200 mg 1 kg orally) and pineapple leaves extract (1 g 1 kg orally) respectively and group E was kept as untreated control. On the basis of faecal egg count of ascaris in calves, ivermectin was found to be more effective (100%), followed by piperazine citrate (100% at 28th day of post-treatment), albendazole (92.95% at 28th day of post-treatment) and pineapple leaves extract (51.21% at 7th day). Total erythrocyte count (TEC), haemoglobin (Hb) and packed cell volume (PCV) values significantly (p < 0.05) increased while erythrocyte sedimentation rate (ESR) significantly (p < 0.05) decreased following treatment. Body weights of treated calves were significantly (p < 0.05) increased in treated calves than the control. Therefore. ivermectin, albendazole and piperazine citate could be used against ascariasis in calves. Although efficacy of pineapple leaves was not encouraging but it may be used as a substitute for other anthelmintics.

Keywords: Comparative efficacy, Anthelmintics, Pineapple leaves, Haematological parameters, Body weight

Location: Upazila Veterinary Hospital, Katiadi under Kishoregonj

Start Date: 00-01-1997

End Date: 00-09-1997

Program Area: Development of Host and Medicinal Plants

Non-commodity: Performance

Objectives:

The present study was undertaken to evaluate the comparative efficacy of pineapple leaves with some other modem anthelmintics and its effects on certain haematological parameters and live body weight gain in cales.

Methodology:

The experiment was performed in the Upazila Veterinary Hospital, Katiadi under Kishoregonj district during the period from January to September 1997. A total of 25 calves heavily infected with ascarid parasites were randomly selected from the surrounding villages to study the comparative efficacy of some modem anthelmintics and the pineapple leaves against ascarid (Toxocara vitulorum) parasite and their effects on body weight as well as certain haem & tological parameters. These calves were under 18 months old of both sexes and were selected on the basis of clinical signs and faecal examination. The calves were divided into 5 groups (A, B, C, D and E) and each group consisting of 5 calves. Each calf of group A, B, C, D was treated with ivermectin (Jvomec®, MSD @ 200 J.Lg 1 kg body weight subcutaneously), albendazole (Aidazole®, Techno Drugs. Bangladesh @ 7.5 mg I kg body weight orally), piperazine citrate (Avipar®, Rhone-Poulenc @ 200 mg 1 kg body weight orally) and pineapple (Ananus sativus) leaves (1 g 1 kg body weight orally) respectively. Calves of groupE were kept as untreated control. The anthelmintic efficacy results were evaluated on the basis of reduction of faecal e g count. Faecal samples were collected from all the 25 ascarid infected calves at pre- and post-treatment (7'11 14 ', 21st and 28th days of post treatment) with different anthelmintics and pineapple leaves. These samples were examined for counting of ascarid eggs per gram (epg) of faeces by modified Stolls' dilution technique as described by Soulsby (1986). The parasitic eggs were identified on the basis of characteristic morphological features as described by Soulsby (1986) and then counted. Three slides were examined for each sample and the mean of eggs was multiplied by 100 and was considered as egg per gram (epg) of faeces. The body weight of all the experimental groups of calves were measured at pre-treatment and 60th day on post treatment. The body weight was measured by using the formula described by Samad (1996). Haematological examinations were carried out in all the groups of calves. About 0.5 ml of venous blood was collected from jugular vein in vial containing EDTA as anticoagulant from each of the experimental calves at pre treatment and on day 28'11 post-treatment. The collected blood samples were brought to the laboratory and the haematological parameters (TEC, Hb content, PCV and ESR) were determined as per method described by Coffin (1955) and Jain (1986). The results were analyzed statistically between treated and control groups by using analysis of variance (Gupta, 1982).

Source of Information: Bangl. J. Vet. Med. (2005). 3 (1): 33-37

Article Link (Online Journal):

Funding Source:

Total Budget (Tk.) :

Achievement/Findings:

It is therefore, concluded that ivermectin, albendazole and piperazine citrate effective against ascariasis in calves. Although efficacy of pineapple leaves is not encouraging, is useful in improving health condition and haematological parameters in calves and may be used for the substitute of other anthelmintics.

Knowledge Management: Journal