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Therapeutic Competence of Dried Garlic Powder (allium Sativum) on Biochemical Parameters in Lead (pb) Exposed Broiler Chickens

Md. Anwar Hossain
Department of Pharmacology and Toxicology, Sylhet Agricultural University, Bangladesh.

Md. Rashedunnabi Akanda
Department of Pharmacology and Toxicology, Sylhet Agricultural University, Bangladesh.

Mahbub Mostofa
Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

Md. Abdul Awal
Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

Abstract/ Executive Summary:

The study was conducted to assess the therapeutic competence of garlic (Allium sativum) in lead (Pb) exposed chickens. The experimental birds (n=350) were grouped into T₀ (as control), T₁, T₂, T₃ and T₄. The birds of group T₁ was provided with lead acetate at 100 mg/kg body weight. Group T₂ had lead acetate at 100 mg/kg b.wt. + 1% garlic supplement, whereas group T₃was fed with lead acetate at 100 mg/kg b.wt. + 2% garlic supplement, and group T₄ had lead acetate at 100 mg/kg b.wt. + 4% garlic supplement. The mean values (mg/dL) of uric acid, blood urea nitrogen, creatinine, cholesterol, triglycerides, low density lipoprotein, high density lipoprotein, and blood glucose in the birds of group T₁ were significantly increased (p<0.01) on day 42 of post-treatment. Elevation of these parameters was suggestive for the pathological involvement of different organs like liver, kidney, muscles. Statistical analysis of variance indicated that lead acetate at 100 mg/kg b.wt. + 2% garlic supplement (T₃) resulted significant (p<0.01) ameliorative effect on the biochemical parameters as compared to the group T₂ and T₄_. In conclusion, potency of garlic in reversion of the values of the biochemical properties in Pb exposed chickens was close to the normal levels of the values.

Keywords: Biochemical parameter, Chelating agents, Chicken Lead

Location: BAU, Mymensingh

Start Date: 00-07-2009

End Date: 00-06-2012

Program Area: Animal Health and Management

Commodity: Chicken

Objectives:

To enhance the values of biochemical parameter by the use of garlic powder in Pb exposed chickens.

Methodology:

Place of work and duration: The experiment was conducted at the Department of Pharmacology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh, during the period of July 2009 to June 2012. Experimental birds: A total of 350 day-old commercial broiler chickens (Hubbard Classic) of both sexes were collected and housed in floor pens. Chicks had an ad libitum access to feed and water. All chicks were weighed individually at day 1, 7, 14, 21, 28, 35 and 42. The diets for the chicks were formulated according to US National Research Council guidelines. Chickens were reared under standard management conditions throughout the experimental course. Use of lead acetate and garlic (Allium sativum) in different treatment groups: The chicks were randomly assigned to five (5) separate pens named Group T₀_,T₁, T₂, T₃ and T₄; in which 70 birds contained in eachgroup. Group T0 was kept as control group. Group T₁, T₂, T₃ and T₄, were treated with only lead acetate (dosed at 100 mg/kg b.wt.), lead acetate (dosed at 100 mg/kg b.wt.) + 1% garlic supplement, lead acetate (dosed at 100 mg/kg b.wt.) + 2% garlic supplement, and lead acetate (dosed at 100 mg/kg b.wt.) + 4% garlic supplement, respectively. The experimental course was operated for 42 uninterrupted days. Control diet was free from both dietary garlic (Allium sativum) and lead acetate. Diets were formulated from the locally commercially available ingredients. Garlic was prepared without skin and dried in a Freeze Drier Model (LABCONCO) for 72 h, and then ground to become powder. Analytical grade lead acetate used in this study was obtained from Merck Company Ltd. (Germany). Garlic (Allium sativum) was locally purchased. The doses of lead acetate and garlic were based on other studies (Hanafy, 1994; Ashour, 2002; Yassin, 2005).

Source of Information: J. Adv. Vet. Anim. Res., 1(4): 189-195.

Article Link (Online Journal):

Funding Source:

Total Budget (Tk.) :

Achievement/Findings:

The finding reveals that garlic (Aullium sativum) might have therapeutic ability on Pb-exposed broiler chickens. It indicates that garlic might have contained chelating compounds capable of altering the biochemical parameter. Therefore, the findings could be useful to understand its’ useful protection. The garlic supplement was found significant, which could be recommended for achieving optimum effects of chelation therapy in Pb-exposed broiler chickens.

Knowledge Management: Journal