Agricultural Research Management Information System

Home
Research Summary
Search
About Us
- ARMIS
- Brochure
Contact Us
Report
User Request
Data Input
Help
- Operation Manual
  - PDF
  - Video
- Program Area & Commodity
We have reached 37600 number of research entries at this moment.

- Logout

Research Detail

Home
Research
Detail

Sedation of Xylazine and Lignocaine with Adrenaline and Bupivacaine for Umbilical Surgery in Calves

NC Sarker
Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh 2002, Bangladesh

MA Hashim
Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh 2002, Bangladesh

BP Ray
Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh 2002, Bangladesh

SK Sarker
Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh 2002, Bangladesh

Abstract/ Executive Summary:

Context: The use of sedatives in veterinary practice is indispensable as they help in overcoming resistance of the animal during examination, maintaining depth of anaesthesia, reducing the dose of anaesthetic agent and increasing the margin of safety. Thus, action of some sedatives and local analgesics in various regional anaesthesia in calves and their evaluation in respect of doses are of great significance. The approximation of dose rate of available sedatives in calves may be helpful for the practitioners. Objectives: To determine the general effect of clinically useful dose of the sedatives produced by xylazine and lignocaine with adrenaline and bupivacaine for umbilical surgery in calves. Materials and Methods: The experiment was performed on 20 affected with umbilical hernia, 6 were indigenous (local) and 14 were crossbred. They were divided into 4 groups and each group included 5 calves. Groupp A was sedated with xylazine hydrochloride and 2% lignocaine hydrochloride; Group B with xylazine hydrochloride followed by 0.5% bupivcaine hydrochloride; Group C with diazepam followed by 2% lignocaine hydrochloride; and Group D diazepam followed by 0.5% bupivacaine. Respiratory rate, heart rate and rectal temperature were recorded before administration of sedatives and at 15, 30, 45, 60 minutes after sedation and local analgesia. Results: Heart rate and respiration rate significantly (p<0.01) decreased during sedation with xylazine hydrochloride plus 2% lignocaine hydrochloride or 0.5% bupivacaine hydrochloride. A significantly decreased (p<0.01) heart rate and respiration rate also found during sedation with diazepam plus 2% lignocaine hydrochloride or 0.5% bupivacaine hydrochloride. Duration of analgesia was longer with 0.5 % bupivacaine hydrochloride (55.88 ± 1.58 min in Group B and 48±11.25 min in Group D) compared to 2% lignocaine hydrochloride (39.60 ± 5.77 min in Group A and 43.6 ± 5.81 min in Group C). Xylazine hydrochloride showed short onset and long duration of sedation compared to diazepam. Conclusion: For herniorraphy, xylazine hydrochloride can be used as a better sedative while 0.5 % bupivacaine hydrochloride can be used as a local analgesic for longer duration of action.

Keywords: Xylazine, Lignocaine, Diazepam, Sedation, Analgesia.

Location: Operation theatre of veterinary clinic, Bangladesh Agricultural University, Mymensingh, Gaibandha, Sirajgang and Kurigram Districts.

Start Date:

End Date:

Program Area: Animal Health and Management

Commodity: Calf

Objectives:

To determine the general effect of clinically useful dose of the sedatives produced by xylazine and lignocaine with adrenaline and bupivacaine for umbilical surgery in calves.

Methodology:

Experimental Animal: The experimental work was carried out in the operation theatre of veterinary clinic, Bangladesh Agricultural University, Mymensingh, Gaibandha, Sirajgang and Kurigram Districts. The experiment was performed on 20 calves of ages ranging from 5 days to 4 months and body weights varied from 20 to 48 kg. Out of 20 calves affected with umbilical hernia, 6 were indigenous (local) and 14 were crossbred. They were divided into 4 groups and each group included 5 calves. The calves were apparently healthy. The animals were starved of both food and water for 3 hours before sedation. An assistant restrained the animal physically and the drug was injected intramuscularly. Use of Sedatives: Xylazine hydrochloride (Rompum®), lignocaine hydrochloride (Jasocaine®), bupivacaine hydrochloride (Ultracaine®), and Diazepam (Seduxen®); all from Jayson Pharmaceuticals Ltd. Bangladesh were used for the study. The experiments were done in four groups: Group A: Firstly xylazine hydrochloride was injected at a dose rate of 0.1 mg kg-1 body weight intramuscularly. Ten minute later 2% lignocaine hydrochloride was injected at a dose rate of 10 ml and then required dose for local infiltration. Group B: The animals were sedated using xylazine hydrochloride @ 0.11 mg kg-1 intramuscularly and were local analgesized using 0.5% bupivcaine hydrochloride ten minute later for local infiltration. Group C: At first diazepam was injected at a dose rate of 0.5 mg kg-1 body weight intramuscularly. Twenty to thirty minute later 2% lignocaine hydrochloride was injected at a dose rate of 10 ml and then required dose for local infiltration. Group D: Twenty to thirty minute prior to analgesia diazepam was injected at a dose rate of 0.5 mg kg-1 body weight intramuscularly, 0.5% bupivacaine hydrochloride was injected at a dose rate of 10ml and then required dose for local infiltration Observation in animals: Immediately after injection of drugs the animals were observed for various behavioural changes i.e. changes in attitude, outlook, and posture and time parameters like onset time, down time and recovery time. The depth of sedation and local analgesia were assessed by monitoring variousocular reflexes, pain prick reflexes, relaxation of neck, jaws, salivation, lacrimation, urination and granting, respiration rate, heart rate and rectal temperature were observed. Statistical Analysis: Student’s paired “t” test was performed to compare the obtained before anaesthesia and 15, 30, 45 and 60 min. after anaesthesia. Analysis of variance (ANOVA test) in completely randomized design was carried out to test significance of variation among the effects in different time interval.

Source of Information: J. bio-sci. 18: 134-139, 2010 ISSN 1023-8654

Article Link (Online Journal):

Funding Source:

Total Budget (Tk.) :

Achievement/Findings:

For herniorraphy, xylazine hydrochloride can be used as a better sedative while 0.5 % bupivacaine hydrochloride can be used as a local analgesic for longer duration of action.

Knowledge Management: Journal