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Evaluation of the Efficacy of Baby Chick Ranikhet Disease Vaccine and Bangla Baby Chick Ranikhet Disease Vaccine in Fayoumi Chicks.

Zafar Ahmed Bhuiyan
Department of Microbiology, Chittagong Veterinary University, Pahartali 4202, Chittagong, Bangladesh.

Paritosh Kumar Biswas
Department of Microbiology, Chittagong Veterinary University, Pahartali 4202, Chittagong, Bangladesh.

ZafM Nural Anwar
Department of Microbiology, University of Chittagong, Chittagong 4331, Bangladesh.

Abdul Ahad
Department of Microbiology, Chittagong Veterinary University, Pahartali 4202, Chittagong, Bangladesh.

Nitish Chandra Debnath
Department of Microbiology, Chittagong Veterinary University, Pahartali 4202, Chittagong, Bangladesh.

Abstract/ Executive Summary:

A study was undertaken for testing the comparative efficacy of two live vaccines produced in Bangladesh to control Newcastle disease (ND) in chickens. One of these vaccines named ‘baby chicks Ranikhet disease vaccine (BCRDV), a government vaccine produced by the Livestock Research Institute, Mohakhali, Dhaka, and the other named ‘Bangla-BCRDV®’, a commercial vaccine produced recently by a pharmaceutical company. Both the vaccines are prepared using the ‘F’ strain of Newcastle disease virus (NDV). Three hundred Fayoumi chicks distributed in 3 groups were used in this study. The results of this study revealed that, at the age of 49 days the survival rates of chicks belonged to BCRDV, Bangla-BCRDV® and control groups were 69, 11 and 18%, respectively. The survival rate of Fayoumi chicks in the BCRDV group was significantly higher than that of the two other groups (p <0.05). Conversely, almost similar survival rates of chicks were recorded in the control and Bangla-BCRDV® groups (p >0.05). At day-1, the haemagglutination inhibition (HI) titre to NDV of the chicks was log2 5.8 ± 0.79 (SEM). At day 35 the same HI titre was observed in the chicks of the BCRDV group, which was, 1 and 1.5 log (base 2) higher than the chicks of the control and Bangla-BCRDV® group, respectively. At day-49, HI titres to NDV ≥ log212 were recorded in the chicks of all the three groups that survived having challenged with velogenic NDV. There were no significant differences in weekly mean body-weights of the chicks in all the three groups until the week 8 when the mean bodyweight of the chicks was higher in the BCRDV group compared with the two others. These results indicted that the efficacy of BCRDV in Fayoumi chicks against ND was better than the Bangla-BCRDV®.

Keywords: Baby chick ranikhet disease vaccine, Bangla baby chick ranikhet disease vaccine, Newcastle disease (ND), Newcastle disease virus (NDV), Newcastle disease vaccine (NDC)

Location:

Start Date:

End Date:

Program Area: Pest Management

Commodity: Chicken

Objectives:

To evaluate the efficacy of the two vaccines, viz., BCRDV and Bangla-BCRDV® against ND in the Fayoumi chickens.

Methodology:

Two vaccines were used in this experiment, viz., BCRDV (produced by the LRI) and Bangla-BCRDV® (produced by FnF Pharmaceuticals Ltd). Both the vaccines are available in lyophilised forms and they are prepared using the same strain (F, a lentogenic virus) of NDV. The BCRDV was supplied only in 100 doses’ glass-vials without any labelling on the vial; however, it could be identified by the green colour of its contents. In contrast, Bangla-BCRDV® were sold in 300, 500 and 1,000 doses’ vials and on each vial was a brief description of the vaccine including the batch number, and the dates of its production and expiry. Also, a diluent was provided with the Bangla-BCRDV®; distilled water was recommended for BCRDV instead of any specific diluents. Both vaccines could be administered intraoccularlyThree hundred Fayoumi day-old chicks were collected from the Pahartali Zonal Poultry Farm (PZPF), Chittagong, which is a government poultry farm. Generally, in this PZPF, Fayoumi and Rhode Island Red (RIR) breeds were maintained as two parental breeds to produce the Sonali (Crosbred; F1 generation) chicks. The Sonali, and sometimes Fayoumi, chicks were supplied to the rural areas for been reared up by the poor people, particularly by the women, as a part of their income generating activities. Under different poverty amelioration programmes like the SLDP-2, rearing of higher egg-producing hens, especially Sonali and sometimes Fayoumi, were encouraged and facilitated by supplying microcredits. At day 1, randomly selected 10 from the collected chicks were euthanased and sacrificed humanely to take blood sera from them. The remaining chicks were distributed in three groups: Group 1 and Group 3 comprising 125 birds each, and Group 2 was the control group having 40 chicks

Source of Information: Bangladesh J Microbiol, Volume 23, Number 2, December 2006, pp 125-129

Article Link (Online Journal):

Funding Source:

Total Budget (Tk.) :

Achievement/Findings:

The results of this study revealed that, at the age of 49 days the survival rates of chicks belonged to BCRDV, Bangla-BCRDV® and control groups were 69, 11 and 18%, respectively. The survival rate of Fayoumi chicks in the BCRDV group was significantly higher than that of the two other groups (p <0.05). Conversely, almost similar survival rates of chicks were recorded in the control and Bangla-BCRDV® groups (p >0.05). At day-1, the haemagglutination inhibition (HI) titre to NDV of the chicks was log2 5.8 ± 0.79 (SEM). At day 35 the same HI titre was observed in the chicks of the BCRDV group, which was, 1 and 1.5 log (base 2) higher than the chicks of the control and Bangla-BCRDV® group, respectively. At day-49, HI titres to NDV ≥ log212 were recorded in the chicks of all the three groups that survived having challenged with velogenic NDV. There were no significant differences in weekly mean body-weights of the chicks in all the three groups until the week 8 when the mean bodyweight of the chicks was higher in the BCRDV group compared with the two others. These results indicted that the efficacy of BCRDV in Fayoumi chicks against ND was better than the Bangla-BCRDV®.

Knowledge Management: Journal