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Weight Reducing Effect of Oyster Mushroom (pleurotus Ostreatus) on Diabetic Obeys Male Volunteers

Md. Bazlul Karim Choudhury
Ph.D. Student
Jahangirnagar University, Savar, Dhaka and OSD, DG Health, Mohakhali, Dhaka- 1212, Bangladesh.

Taufiqur Rahman
National Mushroom Development and Extension Centre, Sobhanbag, Savar, Dhaka, Bangladesh

Abdus Salam Khan
National Mushroom Development and Extension Centre, Sobhanbag, Savar, Dhaka, Bangladesh

Mahbuba Moonmoon
National Mushroom Development and Extension Centre, Sobhanbag, Savar, Dhaka, Bangladesh

Md. Mominul Hoque
National Mushroom Development and Extension Centre, Sobhanbag, Savar, Dhaka, Bangladesh

Tahera Binte Mujib
National Mushroom Development and Extension Centre, Sobhanbag, Savar, Dhaka, Bangladesh

Noor-A-Jannat Mukta
OSD, Directorate of Secondary and Higher Education, Dhaka, Bangladesh.

M. Shahabuddin Kabir Choudhuri
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka, Bangladesh.

Abstract/ Executive Summary:

To evaluate the weight reducing effect of oyster mushroom (Pleurotus ostreatus), the present study was carried out in Nationl Mushroom Development and extension Center (NAMDEC), Sobhanbag, Savar, Dhaka, on diabetic obeys male volunteers, in association with the Department of Pharmacy, Jahangirnagar University, Savar, Dhaka. Three grams of dried oyster mushroom (Pleurotus ostreatus) powder as capsule form was taken by the subjects in three divided doses for three months. The finding of the study showed a non significant small reduction of the body weight (76.55 ± 1.83 and 75.82 ± 1.88, p = 0.193) and body mass index (BMI) (27.50 ± 0.39 and 27.23 ± 0.40, p = 0.184). These findings suggest that regular consumption of a considerable amount of Pleurotus ostreatus may able to reduce the body weight of diabetic male human subjects.

Keywords: BMI, Body weight, Diabetes, Obesity, Pleurotus ostreatus.

Location: Laboratory of Strengthening Mushroom Development project, National Mushroom Development and Extension Center (NAMDEC), Sobhanbag, Savar, Dhaka, Bangladesh

Start Date: 00-01-2009

End Date: 00-06-2012

Program Area: Food Safety and Security

Commodity: Mushroom

Objectives:

To observe the effect of Pleurotus ostreatus on diabetic obeys volunteers to determine its anti - obesity effect.

Methodology:

The study was conducted during the period of January 2009 to June 2012 in the laboratory of Strengthening Mushroom Development project, National Mushroom Development and Extension Center (NAMDEC), Sobhanbag, Savar, Dhaka in association with the department of Pharmacy and department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka. A total of 20 diabetic male obeys (and over weight) volunteers (fasting plasma glucose 7 to 18.6 mmol/l) age range (years) from 28 to 61 were included in the study after taking their informed written consent. They were free from renal impairment (plasma creatinine 0.6 to 1.2 mg/dl) and other known acute or chronic diseases. Persons with a history of addiction other than smoking were excluded from the study. The subjects were allowed to continue the medication (if any) they were taking. Age, sex, occupation, educational status, marital status, family history and drug history were recorded in a preformed data collection sheet. At the beginning of the study, subjects were evaluated for health status. Mean of duplicate measurements was taken. Height and weight of the subjects were taken with light cloths without shoes. Trained workers took these measurements using the standard measuring tools. Body Mass Index (BMI) of the subjects was calculated. BMI = Weight in kg / Height in meter 2. With all aseptic precautions, 10 ml of fasting blood was collected from median cubital vein. Immediately after collecting, blood was poured into fluoride and EDTA containing test tube. The test tube was then gently shaken for proper mixing with the anticoagulants. This anticoagulant-mixed blood was centrifuged at 3000 rpm for 5 minutes. Separated plasma was transferred into two eppendorf containing 1 ml in each. Plasma glucose level was estimated using enzymatic Glucose oxidase method and plasma creatinine was estimated by alkaline picrate method. Analysis was performed by semi auto biochemical analyzer 3000 evaluation using commercially available reagent kit. All the tests were carried out as early as possible. Fresh fruiting bodies of Pleurotus ostreatus were collected from culture house of National Mushroom Development and Extension Centre (NAMDEC). Collected mushrooms were dried with hot air oven at 40⁰C for 48 hours at moisture level 4-5%, then pulverized and poured into capsule shells which contain 500 mg powder. Mushroom capsules containing 500 mg Pleurotus ostreatus powder in each were supplied to take two capsules three times daily, so that each subject took 3 gm mushroom powder daily. After the end of three months the subjects were re-evaluated and all the investigations were repeated. Results were expressed as mean ± SE. Paired Student’s ‘t’ test was used to see the level of significance. 95% confidence limit was taken as level of significance.

Source of Information: Bangladesh J. Mushroom. 6(2): 41-47, 2012 (December)

Article Link (Online Journal):

Funding Source:

Total Budget (Tk.) :

Achievement/Findings:

Three grams of dried oyster mushroom (Pleurotus ostreatus) powder as capsule form was taken by the subjects in three divided doses for three months. The finding of the study showed a non significant small reduction of the body weight (76.55 ± 1.83 and 75.82 ± 1.88, p = 0.193) and body mass index (BMI) (27.50 ± 0.39 and 27.23 ± 0.40, p = 0.184). These findings suggest that regular consumption of a considerable amount of Pleurotus ostreatus may able to reduce the body weight of diabetic male human subjects. Mushrooms contain a lot of different bioactive components, which mainly include triterpenoids, polysaccharides, nucleotides, sterols, steroids, fatty acids, amino acids, soluble proteins, oleic acid, anergosterol peroxide and inorganic ions like Mg, Ca, Zn, Mn, Fe, Cu, Ge etc. These compounds reduce TG accumulation significantly and ultimately may able to reduce the body weight. Although findings of our 3 months trial with supplementation of 3 gms Pleurotus ostreatus powder per day showed a non significant change of body weight of man but it provides a clue that body weight might be reduced by increasing the dose and duration of mushroom consumption, as weight reduction is a slow process. So, it is assumed that regular intake of considerable amount of Oyster mushroom may able to take part on reducing obesity.

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