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Comparative Effects of Oyster Mushrooms on Plasma Lipid Profile of Hypercholesterolaemic Rats

Nuhu Alam
Department of Botany, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

Md. Shahdat Hossain
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.

Abul Khair
Department of Botany, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

S.M. Ruhul Amin
National Mushroom Development and Extension Centre, Savar, Dhaka, Bangladesh.

Asaduzzaman Khan
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.

Abstract/ Executive Summary:

The feeding of hypercholesterolaemic rats with 5% powder of fruiting bodies of oyster mushrooms i.e., Pleurotus ostreatus, P. sajor-caju, and P. florida reduced the plasma total cholesterol level by 37%, 21% and 16%, respectively and triglyceride level by 45%, 24% and 14%, respectively. LDL/HDL ratio decreased by 64%, 45% and 41% for P. sajor-caju, P. ostreatus, and P. florida fed rats, respectively. Mushroom feeding also reduced body weight slightly in hypercholesterolaemic rats. However, it had no adverse effect on plasma bilirubin, creatinin and urea nitrogen level. The present study reveals that 5% oyster mushroom supplementation provides health benefits, at least partially, by acting on the atherogenic lipid profile in the hypercholesterolaemic condition.

Keywords: Comparative effect, Oyster mushrooms, Lipid profile, Hypercholesterolaemic rats.

Location: National Mushroom Development and Extension Centre, Savar, Dhaka, Bangladesh.

Start Date:

End Date:

Program Area: Socio-economic and Policy

Commodity: Mushroom

Objectives:

To generate awareness of the beneficial effects of edible mushrooms, particularly of oyster mushrooms, on hypercholesterolaemia, which poses serious health problems in both developed and developing countries.

Methodology:

Twenty five young Long Evans rats (Rattus rattus) of 114 ± 12g (mean±SD) were used in the present study. Rats were housed in animal room at 23 ± 20 C, under 12 h dark-light cycles and then divided randomly into five groups. Rats were fed a basal diet supplemented with, no cholesterol or mushroom (normocholesterolaemic control rats; NC), 1% cholesterol (hypercholesterolaemic rats; HC), 1% cholesterol and 5% powder of Pleurotus ostreatus (HC+PO group rats), 1% cholesterol and 5% powder of Pleurotus sajor-caju (HC+PS group rats), 1% cholesterol and 5% powder of Pleurotus florida (HC+PF group rats). Wheat flower- 50; rice powder- 11; wheat bran-19; casein (non fat)-8; egg white-10; soybean oil-1; table salt-0.5, vitamin mixture-0.25 and mineral mixture-0.25. The composition of vitamin mixture in the diet was as follows (gram/100g vitamin mixture):retinyl acetate-9.5 × 10^-4; cholecalciferol-1.2 ×10^-3; α-tochoferol acetate-0.05; thiamin hydrochloride-2.4; nicotinic acid-12; riboflavin-2.4; D-calcium pantothenate-9.6; pyridoxine hydrochloride-1.2; folic acid-9.5 ×10^-2; vitamin K-0.25; cyanocobalamine-9.5 × 10^-3; inositol-47.95 and ascorbic acid-24.0. The composition of mineral mixture added to diet was as follows (g/100g of mineral): calcium gluconate-28.5; K₂HPO₄-17.3; CaCO₃-26; MgSO₄-12.6; KCl-12.6; CuSO₄-0.06; FeSO₄-0.3; MnSO₄-0.55; NaF-2.5 × 10^-4; KI-9 × 10^-4; sodium molybdate_^-3× 10^-4; SeO_2 ^-3 × 10^-4; CrSO_2 ^-1.5 × 10^-3. Rats were fed for 40 days. Mature fruiting bodies of Pleurotus ostreatus, P. sajor-caju, and P. florida were collected from the National Mushroom Development and Extension Centre, Savar, Dhaka, Bangladesh. The fruiting bodies were dried in sunlight and crushed into powder. The powder was mixed with the basal diet. Low-density lipoprotein cholesterol was calculated as follows: LDL-C = {TC – (HDL-C + TG/5)} And very low density lipoprotein cholesterol was calculated as: VLDL-C = {TC – (HDL-C + LDL-C)}. The correlations were evaluated by simple regression analysis. The statistical program used was SPSS 11.5. (P<0.05 was considered statistically significant).

Source of Information: Bangladesh J. Mushroom. 1(1): 15-22, 2007 (June)

Article Link (Online Journal):

Funding Source:

Total Budget (Tk.) :

Achievement/Findings:

The present results suggest that oyster mushroom ingestion has significant health benefits through the modulation of physiological functions that include various atherogenic lipid profiles in hypercholesterolaemia. Therefore, oyster mushroom may be a good source of nutrition that may also act as a prophylactic against hypercholesterolaemia, hyperlipidaemia and related complications, which are the risk factors of atherosclerosis. Mushroom feeding also reduced body weight slightly in hypercholesterolaemic rats. However, it had no adverse effect on plasma bilirubin, creatinin and urea nitrogen level. The present study reveals that 5% oyster mushroom supplementation provides health benefits, at least partially, by acting on the atherogenic lipid profile in the hypercholesterolaemic condition.

Knowledge Management: Journal