The chemical constituents of water were analyzed after SIDR-2007 in the affected regions of Bangladesh. Thirteen water samples were collected from different rivers, ponds and paddy fields of Bagerhat and Patuakhali districts within 7 days after SIDR and in the following year considered at normal condition. The waters were analyzed for pH, EC, HCO3, TDS, Ca, Mg, K, Na, Cl, S, P, B, Zn, Fe, Mn, Cu, Cd and Pb. The levels of pH, EC, HCO3, TDS, Cl, Ca, Mg, K, Fe and Cd were increased and the concentrations of P, S, B, Na, Zn, Cu, Mn and Pb were decreased at SIDR point. During SIDR condition pH, EC, HCO3, Ca, K, P, Zn and Mn were marginally higher, TDS was thrice, Cl and Mg were twice and Fe and Cd around eight times higher than normal condition. Boron and Na were detected about double, S was around seven times, Cu was ten times and Pb was about twenty six times higher at normal condition as compared to SIDR. Remarkable variations were found in some of the ionic constituents indicated pollution in water. The TDS, Mg, Cl, K, Zn and Mn were detected at toxic level for aquaculture, Fe was toxic for drinking, aquaculture and livestock usage and Cd was toxic for drinking during SIDR time. Significant synergistic relationship was found among Ca-Mg, Ca-Zn, Ca-Cl, Mg-K, Pb-S and Fe-B ions but Zn-S and Cu-Cl ions reflected antagonistic relation at SIDR condition. During normal condition it was found among Ca-Mg, Ca-K, Ca-Na, Ca-S, Mg-K, Mg-Na, Mg-Cl, Mg-P, Mg-S, K-Na, K-Pb, K-Cl, K-P, K-S, Na-Cd, Na-Pb, Na-Cl, Na-S, Cd-Pb, Cd-S, Pb-Cl, Pb-S and Cl-S but Mg-Mn and K-Mn ions reflected antagonistic relation.