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Clinico-haematological Effect of Selected Nsaid in the Treatment of Experimentally Produced Myositis in Goat

M. Aktaruzzaman
Animal Health Research Division, Bangladesh Livestock Research Institute, Savar, Dhaka, Bangladesh.

J. Alam
Animal Health Research Division, Bangladesh Livestock Research Institute, Savar, Dhaka, Bangladesh.

A. Rahman
Department of Medicine, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymenisngh-2202, Bangladesh.

M. M. Hossain
Deptartment of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymenisngh-2202, Bangladesh.

Abstract/ Executive Summary:

The present study was performed in the Department of Medicine and in Veterinary clinic of Bangladesh Agricultural University (BAU), Mymensingh from January to June 2002. Myositis was produced experimentally by injecting oil of turpentine in the gluteal muscles of 4 goats of which 2 goats were given treatment with Diclofenac sodium @1mg/kg body weight (treatment group) for consecutive 3 days and remaining 2 goats were reared as control without giving treatment (control group). All the goats were observed for 7 days. Myositis was characterized by reduced appetite, increased body temperature (1-20F), lameness, local swelling and cellular changes in blood level. The appetite in both groups reduced sharply from 1st day of myositis and improved from day 2 and became normal on 3rd day after treatment. Body temperature reduced to normal level from 2nd day after administration of diclofenac sodium but in control group, it came down in the same condition from 4th day onward. Moderate lameness was observed in all the goats of both groups. In treatment group lameness reduced completely in 100% goats after 2 consecutive days of treatment but in control group similar result was observed on day 6. Moderate local swelling was reduced to normal level in treatment group 2 days post treatment remain moderate in control group. Total leukocyte count (TLC) was increased significantly (p<0.05) in both groups in myositic condition than in healthy condition and it came down to normal level in treatment group 3 days post treatment and in control group it remained higher. Similar changes were observed in Neutrophil count. The number of lymphocyte was reduced significantly (p<0.05) in myositic condition than in healthy ones which again reached to normal level within 3 days of treatment.

Keywords: Myositis, Goat, Non-steroidal anti-inflammatory drug

Location: Department of Medicine and Veterinary Clinic of Bangladesh Agricultural University (BAU), Mymensingh, Bangladesh.

Start Date: 00-01-2002

End Date: 00-06-2002

Program Area: Animal Health and Management

Commodity: Goat

Objectives:

To evaluate the therapeutic efficacy of diclofenac sodium in the treatment of experimentally produced myositis in goats.

Methodology:

A total of 4 Black Bengal goats of either sex were randomly divided into two groups (treatment and control group) of 2 animals in each. The goats were aged between 1 to 1.5 years and their body weights ranged between 10-12 kg. The goats of both groups were kept on grazing and sheltered in two different stalls of the Veterinary Clinic at night. Myositis was produced by injecting 2 ml oil of turpentine per animal into the gluteal muscle of one leg in all the animals. After development of myositis the animals of treatment group were treated with Diclofenac sodium (Opsonin) @ 1 mg/kg body weight intramuscularly daily for 3 successive days and goats of the control group were reared without giving any treatment. Blood samples were collected before production of myositis and everyday after production of myositis for up to 3 days from all the animals of both groups. Parameters studied were (a) body temperature before giving treatment and after myositic condition once daily for 7 days, (b) appetite was recorded by eating behavior, (c) local swelling and lameness after production of myositis, and were graded as mild (+), moderate (++), and severe (+++) and were recorded daily for 7 days and (d) total leukocyte count (TLC) and differential leukocyte count (DLC) according to method. Data were statistically analyzed using analyses of variance (ANOVA) technique by using computerized statistical program (SPSS, Version-7.5) in accordance with the principle of the Completely Randomized Design Steel and Torrie, (1980). Data from premyositic or normal condition, myositic condition and after the course of treatment were compared only.

Source of Information: Bangl. J. Vet. Med. (2008). 6 (1): 99–102

Article Link (Online Journal):

Funding Source:

Total Budget (Tk.) :

Achievement/Findings:

The appetite in both groups reduced sharply from 1st day of myositis and improved from day 2 and became normal on 3rd day after treatment. Body temperature reduced to normal level from 2nd day after administration of diclofenac sodium but in control group, it came down in the same condition from 4th day onward. Moderate lameness was observed in all the goats of both groups. In treatment group lameness reduced completely in 100% goats after 2 consecutive days of treatment but in control group similar result was observed on day 6. Moderate local swelling was reduced to normal level in treatment group 2 days post treatment remain moderate in control group. Total leukocyte count (TLC) was increased significantly (p<0.05) in both groups in myositic condition than in healthy condition and it came down to normal level in treatment group 3 days post treatment and in control group it remained higher. Similar changes were observed in Neutrophil count. The number of lymphocyte was reduced significantly (p<0.05) in myositic condition than in healthy ones which again reached to normal level within 3 days of treatment.Form this study it appeared that diclofenac sodium is effective in the treatment of clinical myositis which is moderate. It is also effective to return cellular changes that are leucocytic responses of blood in normal level that either increased or decreased during myositic condition produced experimentally by injecting oil of turpentine.

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