An experiment was carried out to investigated the effect of manuring and irrigation on the growth and yield of passion fruit at the Germplasm Centre (GPC) of Fruit Tree Improvement Programme (FTIP), Department of Horticulture, Bangladesh Agricultural University, Mymensingh, during the period from March, 2011 to March, 2012.The experiment comprised of two factors manures (T1= Cowdung 5kg, T2= Cowdung 10 kg, T3= Cowdung 15 kg, T4= Cowdunng 20 kg, T5= Paragon compost 2 kg, T6= Paragon compost 4 kg, T7= Paragon compost 6 kg )and Irrigation (I = Irrigation, NI = Non-irrigation). The experiment was laid out in randomized complete block design (RCBD) with three replications. Both manures (Cowdung and Paragon compost) and irrigation (Irrigation and Non-irrigation) showed significant influence on growth and yield of passion fruit. The plant height, number of branch, time of flowering, time of fruiting, number of fruits, length, breadth, thickness of fruit, total weight of fruits, peel weight, pulp weight, number of seed, seed weight, total soluble solids (TSS) were significantly higher when T7 (Paragon compost) treatment were applied. The plant height, number of branch, time of flowering, time of fruiting, number of fruits, length, breadth, thickness of fruit ,total weight of fruits, peel weight, pulp weight, number of seed, seed weight, Total Soluble Solids (TSS) were also significantly higher in non irrigated plant. The treatment combination of T7NI (Paragon compost and non irrigation) produced highest plant height, number of branch, time of flowering, time of fruiting, number of fruits, length, breadth, thickness of fruit, total weight of fruits, peel weight, pulp weight, number of seed, seed weight, total soluble solids (TSS) and the lowest values of all above mentioned parameters were obtained from the treatment combination of T8I (Control and irrigation).