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Comparative Clinical Competence of Two Commercial Injectable Ivermectin Against Caprine Haemonchosis (haemonchus Contortus)

Md Rashedunnabi Akanda
Department of Pharmacology and Toxicology, Sylhet Agricultural University, Bangladesh

Md Siddiqul Islam
Department of Pharmacology and Toxicology, Sylhet Agricultural University, Bangladesh

Md Anwar Hossain
Department of Pharmacology and Toxicology, Sylhet Agricultural University, Bangladesh

Abdullah Al Masud
Upazilla Livestock Office, Bishwanath, Sylhet, Bangladesh

Abstract/ Executive Summary:

The foremost purpose of the study reported here was to perform a pharmacological evaluation of two different injectable ivermectin for-mulations in goats infected with haemonchosis. Twenty one (n=21) goats were randomly divided into three groups A, B and C whereas each group consisted of seven (n=7) goats. Product A and Product B were injected subcutaneously to the goat in group A and group B, respectively. Goat in group C was kept as infected control group giving any treatment. With 7th, 14th, 21th and 28th days of treatment, a significantly (P<0.01) decreased of egg per gram (EPG) count was found in treated goat of group A and B, respectively. In experimental period, the EPG count of control group C were significantly (P<0.01) increased. In group A and B reduction of mean EPG on 7th, 14th, 21th and 28th day after treatment were 83.9%-80.8%, 81.7%-80.7, 78.1%-77.0% and 73.7%-61.2%, respectively, whereas in control group C the mean EPG were 6.7%, 9.2%, 21.4% and 30.9%, respectively. The body weight was increased significantly (P<0.01) after treatments in group A and B, respectively except untreated control group C. To sum up, two commercial products contain ivermectin have similar clinical competence against haemonchosis in goat.

Keywords: Clinical Competence, Goat, Ivermectin, Haemonchosis

Location: Department of Pharmacology and Toxicology, Sylhet Agricultural University

Start Date:

End Date:

Program Area: Animal Health and Management

Commodity: Goat

Objectives:

To determine the comparative clinical efficacy of two ivermectin product on haemoncosis in goats.

Methodology:

Study duration and study animal - The study was conducted for a period of 28 days. About twenty one (n=21) Black Bengal goats weighing between 14 to 16 kg were selected on the basis of their age, sex and breed. The animals were maintained in intensive husbandry condition and supplied with sufficient water and feed per day. Total goats were randomly divided 3 groups. Two injectable ivermectin formulations (Acimec®, ACI Ltd. and Amectin®, Acme Lab. Limited, Bangla-desh) were used (0.2 mg/kg, SC) for positive control against Haemoncus sp. as Group A and B. Goats of group C was kept as control without giving any treatment. Before trials day 0, initial body weight, total egg per gram count of parasites were recorded. During the study period the fecal samples were collected directly from the rectum. Egg per gram count - EPG count by using Modified Stoll’s egg counting method on 7th, 14th, 21th and 28th day, respectively. Measurement of body weight - The body weight of all cattle was taken as: Body weight = Length x (Girth) 2/300 x 2.2 kg, Here Length = Length from the point of shoulder to the buttock in inches. Girth was also measured in inches at the point of xyphoid carti-lage. Body weights were recorded on day 7, 14, 21 and 28 following the treatments of goats. Statistical analysis - The collected data were statistically analyzed by using statistical programmed MSTAT-C. A one way ANOVA was done by F variance test.

Source of Information: International Journal of Biological Research, 2 (2) (2014) 96-98

Article Link (Online Journal): doi: 10.14419/ijbr.v2i2.3296

Funding Source:

Budget:

Total Budget (Tk.) :

Achievement/Findings:

The present finding revealed that both commercial products are effective for reduction of EPG of haemonchosis in goats. These two drugs have wide therapeutic index and they may kill or inhibit egg production of gastro-intestinal haemonchosis. However, the preliminary control efficacy studies of anthelmintics may help to explore the details of pharmacokinetic study.

Knowledge Management: Journal