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Studies of the Comparative Efficacy of Alcoholic Extracts of Bironja, Turmeric, and Veranda Leaves with That of Patent Drug Nilzan Agains Trematodiasis in Sheep

Tahmina Begum
Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

Bayzer Rahman
Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

Sukumar Saha
Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

Mahbub Mostofa
Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

Md. Abdul Awal
Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

Abstract/ Executive Summary:

The study compared the efficacy of some indigenous plants (Bironja, Turmeric and Veranda leaves) with that of patent drug Nilzan against Trematodiasis in sheep. Seventy five sheep suffering from trematode, aged 2-3 years and weighing about 10- 12 kg. were used for this study. The sheep were divided into 15 equal groups A, B, C, D, E, F, G, H, I, J, K, L, M, N and O. Administration of three different doses of powdered Bironja 3,6 & 9 ml /kg body wt to the group A, B, C, D and E, Turmeric at the dose rate of 2,4 & 6 ml /kg body wt to the groups F, G, H, I and J, Veranda leaves 2, 4 and 6 ml /kg body wt to the groups K, L, M, N and O showed 15-52% , 11-15% and 4-8% efficacy, respectively against trematodes in sheep. Administration of Nilzan 30 mg/kg body wt orally was highly effective 73-89% against all the species of trematodes in sheep. Among medicinal plants Bironja was found to be most effective followed by turmeric. Veranda leaves were found to be totally ineffective against trematodiasis in sheep.

Keywords: Efficacy,Trematodiasis, Sheep, Medicinal plants

Location: BAU campus.

Start Date:

End Date:

Program Area: Animal Health and Management

Commodity: Extract (plant, seed), Sheep

Objectives:

To evaluate the efficacy of Biranja, Turmeric and verenda against trematodiasis in sheep.

Methodology:

Eighty five sheep of indigenous breed were collected from adjacent area of BAU, Mymensingh. The sheep were allowed to graze on pasture of the BAU campus for about one month. These sheep were suspected to be suffering from helminth by observing clinical sign and symptoms. Microscopic examination of faeces of the suspected sheep was carried out for trematode egg count. Seventy five sheep were selected for this study on the basis of the physical and clinical examination and result of the fecal egg count. The age of sheep ranged between 2 and 3 years approximately. The weight of all selected sheep ranged between 10 and 12 kg.Bironja and turmeric were purchased from local market. The veranda leaves were collected from Bangladesh Agricultural University campus. The collected sample were washed thoroughly with water, the veranda leaves and turmeric were cut into small pieces and sun dried for seven days. Then these samples were dried separately in a hot air woven at 45°C for six hours. The dried samples were taken into equal parts by measuring with balance and pulvarised to 60 meshes in a grinding machine separately.100 gm of each sample was stored in air tight bottle separately. Alcoholic extracts of selected medicinal plants were obtained by Soxlet method. The alcoholic extracts of each kind of sample was then kept in separate air tight bottle and labeled for further study. Biochemical parameters like serum glucose and SGPT (serum glutamic pyruvic transaminase) were also determined by using autoanalyser (Model No.Reflotron M - 06 ). Nilzan(Tetramizol hydrochloride and oxyclozanide) was purchased from local market. Diagnostic kit(Glucose, SGPT) test combination used in this study were purchased from Fisons Bangladesh Ltd. Anticoagulant Haymes solution,0.14 hydrocloric acid solution, Wrights stain, 90% alcohol,10% formalin, normal saline (0.09) saturated salt solution , were prepared in the laboratory. The data was analyzed statistically between normal and treated values by the well - known students test (t” test).

Source of Information: Res. Agric., Livest. Fish.3(1): 165-174, April 2016, ISSN: 2409-0603

Article Link (Online Journal): DOI: http://dx.doi.org/10.3329/ralf.v3i1.27873

Funding Source:

1.

Budget:

Total Budget (Tk.) :

Achievement/Findings:

Among the medicinal plants, Bironja seeds was found to be most effective followed by Turmeric. Veranda leaves was found to be totally ineffective against tramatodiasis in sheep. No significant change was observed following treatment with Bironja seeds, Turmeric and Verenda leaves and Nizan on serum glucose and SGPT in sheep.Therefore it can be concluded that the patent drug Nilzan is highly effective against trematodes in sheep. However, among the medicinal plants, Bironja seeds and turmeric may be used against trematodes when patent drugs are not available or become out of reach for the poor farmers of Bangladesh.

Knowledge Management: Journal