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Effect of Hibiscus Rosasinensis on the Liver of Swiss Albino Mice: a Histo-morphological Investigation

S Bhakta
Bioresearch Laboratory, Department of Anatomy and Histology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh

SK Das
Bioresearch Laboratory, Department of Anatomy and Histology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh

Abstract/ Executive Summary:

Nature has been a source of medicinal agents for the thousands of years and a large number of drugs have been isolated from natural sources. Over 50% of all modern drugs are originated from natural sources. Hibiscus rosasinensis is also a very renowned flower having a vast use as a medicinal plant. Several studies have shown that the flower, leaf of this plant has a wide range of medicinal uses such as contraception, anti-nociceptive, anti- inflammatory, anti-allergic, anti-tumor, anti-diarrheic and anti-convulsent. But whether this plant affects the liver or not is still not investigated with proper care. For the sake of this purpose a research was conducted on the Swiss albino mice in the Bioresearch Laboratory, Department of Anatomy and Histology, Bangladesh Agricultural University, Mymensingh-2202. Twenty (20) mice (Avg. weight of 27-28 gm and avg. age of 6-7 weeks) were purchased from ICDDR,B, Mahakhali, Dhaka and divided into two groups (control, C and Treated, T) each having 10 mice. During the experimental period, the control group was supplied with the normal mice pellet and plane water whereas, the powder of the Hibiscus rosasinensis @ 500 mg/ml with drinking water and the normal mice pellet was provided to the treated group. After the end of the experimental tenure of one month the mice were sacrificed ethically and sample (liver) was collected for the gross and histological analysis. Both in the gross and histology the histomorphology of the liver was similar without having any alteration from the normal. No remarkable changes of the gross and histological architecture were found. So it can be said that the extract of Hibiscus rosasinensis has no baleful effects on the histomorphology of the liver in Swiss Albino mice.

Keywords: Hibiscus rosasinensis, Liver, Histomorphology, Mice

Location: Bioresearch Laboratory, Department of Anatomy and Histology, Bangladesh Agricultural University, Mymensingh-2202

Start Date:

End Date:

Program Area: Development of Host and Medicinal Plants

Non-commodity: Performance

Objectives:

The present research was conducted to find out the effects of the flower of the Hibiscus rosasinensis on the liver, whether it affects the normal architecture or not.

Methodology:

Twenty (20) experimental animal, Swiss albino mice (at the age of 6-7 weeks and avg. weight 27-28 gm) were collected from ICDDR,B, Mahakhali, Dhaka and divided into two (2) groups such as Control (C) and Treated (T) groups, each having ten (10) mice. Prior the treatment of the mice they were reared for 2 weeks for being accustomed with the environment. During that period both the control and treated group were supplied with the normal feed and water. After that the treatment period started. During the treatment period, the control group was fed with the normal mice pellet and water whether the treated group was given powder of Hibiscus rosasinensis flower along with water @ 500 mg/ ml, but normal mice pellet was also provided. The experimental tenure was for 30 days and during the period all the management practices were uniform for both the control and treated groups. After the end of the experimental tenure the mice (both the control and treated groups) were sacrificed ethically and the sample (liver) was collected, processed, stained and observed under the microscope for investigating the architectural deviation from the normal in both gross and histology.

Source of Information: Progressive Agriculture 27 (3): 296-300, 2016

Article Link (Online Journal):

Funding Source:

Budget:

Total Budget (Tk.) :

Achievement/Findings:

The use of Hibiscus rosasinensis is safe as a medicinal plant as it does not have any harmful effects on the histomorphology of liver in both the gross and histology. It does not affect the normal architecture of the liver in the gross and histology. So the further research on the dose determination, phytochemical investigation and standardization should be continued for promoting this plant extract as a patent one.

Knowledge Management: Journal