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Efficacy of Sulfadiazine and Trimethoprim for the Treatment of Infectious Coryza and Enrofloxacin for Pullorum Disease in Commercial Layer Birds

M. A. H. Mondal
Department of Medicine , Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh & Doctors Poultry and Dairy Lab, Aziz Fokir Market, Mawna, Sreepur, Gazipur

M. M. Rahman
Community-based Dairy Veterinary Foundation, Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh

M. M. U. Bhuiyan
Community-based Dairy Veterinary Foundation, Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh

M. Shamsuddin
Community-based Dairy Veterinary Foundation, Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh & International Atomic Energy Agency, Austria, Vienna

M. T. Islam
Department of Medicine , Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh

Abstract/ Executive Summary:

This study was conducted in the Bismillah Poultry Farm and Orkid Poultry Farm, Sreepur, Gazipur to evaluate efficacy of sulfadiazine and trimethoprim, and enrofloxacin against infectious coryza and pullorum disease in commercial layer birds. A total of 300 birds affected with infectious coryza in the Bismillah Poultry Farm were treated with two commercial preparations of sulfadiazine and trimethoprim, Ativet (Acme) and Trimsul 80/400 (DutchFarm). Four hundred birds affected with pullorum disease in the Orkid Poultry Farm were treated with two commercial preparations of enrofloxacin, Enrovet (Acme) and Komibiotril (Komipharm). In case of infectious coryza, subsidence of facial swelling, decrease in serous nasal exudates and purulent ocular discharge, decrease in sneezing and dyspnea were excellent within 5 days of treatment with both Ativet (Acme) and Trimsul 80/400 (DutchFarm), and the recovery rate was 93.3% and 92%, respectively. In case of pullorum disease, subsidence of whitish to yellowish diarrhea and reduction of drowsiness were excellent within 4 to 5 days of treatment with both the antibiotics, Enrovet (Acme) and Komibiotril (Komipharm). However, reduction of paleness of comb and wattle was not so excellent within 5 days of treatment. The recovery rate for Enrovet and Komibiotril was 92.5% and 94.5%, respectively.

Keywords: Sulfadiazine, Trimethoprim, Infectious coryza, Pullorum disease, Enrofloxacin, Layer birds

Location: Bismillah Poultry Farm and Orkid Poultry Farm, Sreepur, Gazipur

Start Date: 00-09-2011

End Date: 00-08-2012

Program Area: Animal Health and Management

Commodity: Poultry

Objectives:

The clinical efficacy of potentiated sulfonamides and enrofloxacin in the treatment of infectious coryza and pullorum disease in commercial layer birds respectively.

Methodology:

This study was conducted in the Bismillah Poultry Farm and Orkid Poultry Farm, Sreepur, Gazipur during the period from September 2011 to August 2012. The flock size of these two farms was 2000 and 3000, respectively. A total of 300 birds in the Bismillah Poultry Farm were affected with infectious coryza. Diagnosis was made on the basis of clinical signs like swelling of the face and eyes, presence of serous nasal exudates and purulent ocular discharge, sneezing and dyspnoea, and loss of condition due to inappetence, and for confirmation haemagglutination inhibition test was performed. A total of 400 birds in the Orkid Poultry Farm were affected with pullorum disease. Diagnosis was made on the basis clinical signs such as thin yellowish diarrhoea, paleness of comb and wattle, and drowsiness, and the post mortem lesions like necrotic foci on the liver. However, for confirmation serum plate agglutination test using Salmonella pullorum color antigen was performed. Drugs used- Trimethoprim (80 mg) and sulphadiazine (400 mg): a) Ativet (Acme Laboratories Ltd., Bangladesh, b) Trimsul 80/400 oral suspension (DutchFarm, Holland). Enrofloxacin: a) Enrovet (Acme Laboratories Ltd, Bangladesh), b) Komibiotril (Komipharm, Korea). Treatment groups- For infectious coryza,a total of 300 layer birds (3 weeks of age) were divided into two groups, namely A (n = 150) and B (n = 150). Birds of group A were treated with Ativet (Acme), and of group B with Timsul 80/400 oral suspension (DutchFarm) orally through drinking water @ 1 litre/2000 litres of water for 5 days. Pullorum disease affected birds (2-3 weeks of age) were divided into two groups, namely C (n = 200) and D (n = 200). Birds of group C received Enrovet (Acme) orally through drinking water @ 1 litre/1000 litres water for 5 days while birds of group D were treated with Komibiotril (Komipharm) with same dose and duration. In addition, Respiron and herbal liver tonic were used in both the group. Birds were monitored twice daily to record recovery of clinical signs.

Source of Information: Bangl. J. Vet. Med. (2016). 14 (1): 1-4

Article Link (Online Journal): DOI: https://doi.org/10.3329/bjvm.v14i1.28808

Funding Source:

Budget:

Total Budget (Tk.) :

Achievement/Findings:

In case of pullorum disease, subsidence of whitish to yellowish diarrhea and reduction of drowsiness were excellent within 4 to 5 days of treatment with both the antibiotics, Enrovet (Acme) and Komibiotril (Komipharm). However, reduction of paleness of comb and wattle was not so excellent within 5 days of treatment. The recovery rate for Enrovet and Komibiotril was 92.5% and 94.5%, respectively.

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