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Research Detail

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Md. Shariful Islam
Faculty of Life Science, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.

Mamun Mia
Faculty of Life Science, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh

Md. Aminul Islam Apu
Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh.

Joyanta Halder
Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh.

Md. Farzanoor Rahman
Faculty of Life Science, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.

Maidul Islam
Lecturer, Department of Biochemistry and Biotehnology, Khwaja Yunus Ali University, Enayetpur, Sirajgonj-6751, Bangladesh

Nasreen jahan
Lecturer, Faculty of Life Science, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh

Alkaloids are known as low molecular weight heterocyclic nitrogenous compounds naturally derived from amino acid metabolism. Most familiar alkaloids are morphine, strychnine, quinine, ephedrine, nicotine, have a wide distribution in higher plants belonging to Ranunculaceae, Leguminosae, Papaveraceae, Menispermaceae and Loganiaceae families, involved in plant defense against herbivores and pathogens and pronounced bioactivities through the interaction of plants with their environments. At present, medicinal plants and remedies are widely used for various ailments. Many of these plants contain different types of alkaloids are always neurotoxic, pneumotoxic, genotoxic, hepatotoxic and cytotoxic. Alkaloids also have remarkable physiological effects on humans and used to treat Human Immunodeficiency Virus (HIV). Bangladesh is endowed with a very rich flora, and the ancient Bangladesh system of medicine is largely based on plant remedies. For dug designing alkaloids act as a rich reservoir, anti-proliferation, anti-cancer and anti-metastasis both in vivo and in vitro condition. Principal approach with this comprehensive review is to find out various kinds of alkaloids are extracted from plant species and their metabolic activities.

  Alkaloids, Microbicidal, Neurotoxic, Cytotoxic, Anti-proliferation, Nicotine and Anticancer
  Faridpur, Rangpur in Bangladesh
  
  
  Development of Host and Medicinal Plants
  Medicinal Plants

From the ancient time researchers are working heart and soul with medicinal herbs and from them they found to have definite action on the nervous, circulatory, respiratory, digestive and urinary systems; as well as the sexual organs, the skin, vision, hearing and taste. Alkaloids are important phytochemicals of medicinal plants that can be used as vaccine candidates for viruses. Alkaloids have been isolated for their medicinal value from many Bangladeshi plants.

2. Plant based alkaloid and their Activities: 2.1 Glycine max (Fabaceae) Local name: Soya beans. Local region: Faridpur, Rangpur in Bangladesh. Alkaloids and their activities: It is generally known as Soya beans. People generally used its seeds. It contains 3-O-methylD-chiro-inositol active chemical constituents. There are some ingredients of soya beans such as: α-linolenic acid act as essential fatty acid, hypocholesterolemic, hypotriglyceridemic, improves heart health. Isoflavones act as estrogenic, improves the function of digestive tract, prevent prostate and colon cancer. Lecithins improve the metabolism of lipid; the abilities of learning also act as anti-carcinogenic, immunostimulator. Peptides play a good role in reducing body fat. Phytosterols act as hypocholesterolemic. Protein act as hypocholesterolemic, antiatherogenic, body fat reduce. 2.2 Tamarindus indica (Fabaceae) Local name: Tatul tree Local region: Planted throughout Bangladesh. Alkaloids and their activities: Commonly known as Tatul tree, seeds and fruits are its usable portion. It has some active chemical constituents such as flavonoid, polysacc-haride. Tamarindus indica contain some fatty acids studied as methyl ester such as: methyl-nheptanoa, 1-Octanoate, n-Nonanoate, nonanoic acid, nTridecanoic, n-Tetradecanoate, methyl-pentadecanoic, nHexadecanoate, n-Heptadecanoate, n-Octadecanoic, nNonadecanoate, n-Eicosenoate, n-Docosanoate, methyl-ntricosanoate, n-Tetracosane, methyl-n-Pentadecanoic, nHxocosanoate, n-Heptacosanoate, nonacosatrienoic acid, nNnacosanate, detricasonic, 9-Decenoate, pentadecatrienoate, heptadacanoate, heptadecadienoat, 10-Octadecenoicacid oleate, nenodecenoic acid, tetracosadienoate, n-Pentacosenoic acid n-Hexacoseoic acid, 24R-Ethyl cholest-5-en, 3β-ol, 9ß, 19-Cyclo-4 ß4, 4, 14, ß-trimethyl-5ß-cholestan-3ß-ol. 2.3. Allium cepa (Alliaceae) Local name: Piyaj (Bengali) Local region: Cultivated in most of the districts of Bangladesh. Alkaloids and their activities: Allium cepa is usually called onion plant; people generally used its bulb. Onion acts through its active chemical constituents these are S- methyl cysteine sulphoxide and allyl propyl disulphide. [2,4] Research on animal and clinical trials support the use of Allium cepa as anti asthmatic [88, 89], anti diabetic, anti viral anti thrombotic, hypo cholestremic, anti inflammatory, anti oxidant, aphrodisiacs, cardiotonic, diueretic, expectorant, stimulant, anti cancer, platelet aggregation inhibitor, insecticidal properties, and in osteoporosis treatment. 2.5. Azadirachta indica (Meliaceae) Local name: Neem Local region: Planted all over Bangladesh. Alkaloids and their activities: Another important medicinal plant in Bangladesh is Azadirachta indica called neem. Plant’s leaf and seed are used as many medicinal purpose. Nimbidin is its active chemical compound.  Azadirachtin, meliacin, gedunin, nimbidin, nimbolides, salanin, nimbin, and valassin are biologically active phytochemiclas, the four best limnoids compounds are: azadirachtin, salannin, meliantriol, and nimbin having insecticidal and pesticidal activity. Pharmacological actions of this plant are includes antinematodal, antipyretic, antispasmodic, insecticidal, antispermatogenic, antitumor, hypercholesteremic, hypoglycaemic, immunomodulator, abortifacient, analgesic, antihelminthic, antibacterial, antiyeast, antiulcer, antifertility, antifilarial, antifungal, antihyperglycemic, anti-inflammatory, antiviral, antimalarial and diuretic activity. 2.6. Brassica juncea (Brassicaceae) Local name: Mustard Local region: Cultivated in different districts. Alkaloids and their activities: Brassica juncea is locally known as mustard. Seed and leaf are most usable parts. It has isorhamnetindi glucoside as active chemical compound.  Phenolic compounds, carotenoids, glucosinolates are so much rich in this plant which show greater performance of anti-oxidant, hepatoprotective activity, lowering of cardiovascular disease risk and inflammations is performed by linoleic acid and also act as reducing the risk of colon and breast cancer. Active antioxidants such as β-carotene, α- tocopherol, indoles and isothiocyanate are also present. Vegetable of Brassica juncea contain glucosinolates, flavonoids, vitamins and mineral nutrients.

  Journal of Pharmacognosy and Phytochemistry 2015; 3(6): 202-216
  
Funding Source:
1.   Budget:  
  

The above collected information regarding the 20 Medicinal local plants alkaloids and their significance is matched with available literature. Recent years, ethno-botanical and traditional uses of natural compounds, especially of plant origin received much attention as they are well tested for their efficacy and generally believed to be safe for human use. Our main approach with this comprehensive review of traditional plants, together their most active constituents including alkaloids, Flavonoids and Secondary metabolites for vaster and wide range of easy way to find any required information with their Phytochemical constituents and their activity from this comprehensive review. Recent research is now open for any kind of pharmacology based alkaloid extraction, that’s why this review will play a great deal with ethnobotanical research for ayurvedic use of Medicinal plants worldwide. In Figure 1 we try to focus the percentage of alkaloid or secondary metabolites extracts from plants different parts including Leaf, stem, bark, fruits, root etc. The whole review was discussed with 20 plants which is includes the plants parts usable for medicinal treatment, bioactive constituents, and their biological significance.

  Journal
  


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