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Screening of Anticancer Medicinal Plants for Secondary Metabolites

Minhajur Rahman
Department of Botany, University of Chittagong, Chittagong-4331, Bangladesh.

Ataur Rahman
Department of Botany, University of Chittagong, Chittagong-4331, Bangladesh.

ANM Alamgir
Department of Botany, University of Chittagong, Chittagong-4331, Bangladesh.

Abstract/ Executive Summary:

Anticancer medicinal plants contain cancer healing property due to their bioactive secondary metabolites. In the present work, 23 anticancer medicinal plant species representing 10 families of Metachlamydeae were considered for qualitative assessment of the secondary metabolites such as alkaloids, flavonoids, sterols, tannins, glycosides and saponins. All plant parts except the leaf of Leucas aspera gave positive responses to different alkaloid detecting reagents. For 6 other secondary metabolites 13, 14, 9, 15, 9 and 15 cases gave positive responses for flavonoid, sterol, resin, tannin, glycoside and saponin tests, respectively. Results of the screening work for secondary metabolites were discussed in relation to their abundance and distribution in different test plants and their organs.

Keywords: Anticancer, Metachlamydeae, Secondary metabolites, Screening work

Location: Hilly area of Chittagong University campus and around, Bangladesh

Start Date:

End Date:

Program Area: Development of Host and Medicinal Plants

Commodity: Medicinal Plants

Objectives:

In the present work, 23 anticancer medicinal plant species of Metachlamydeae or Sympetalae were considered for phytochemical screening for their secondary metabolites.

Methodology:

Twenty three anticancer medicinal plant species representing 10 families of Metachlamydeae or Sympetalae, enlisted in different published literature were considered in the present work. These plants were collected from the hilly area of Chittagong University campus and around. They were considered in the phytochemical screening work for different secondary metabolites such as alkaloids, flavonoids, sterols, tannins, glycosides and saponins. For alkaloids, the modified method of Webb was followed according to Amarasingham et al. as well as Apline and Cannon. Five alkaloid detecting reagents such as Dragendorff (D), Wagner (W), Mayer (M), Hager (H) and Tannic acid (T) were prepared following Cromwell were used. Flavonoids were determined in the Et-OH extract following Wall et al. and Farnsworth. Sterols, tannins, glycosides and saponins were assessed following Bhattacharjee and Das, Wall et al. and Eyjolfesson respectively. The presence, absence and abundance of different secondary metabolites in the test samples were indicated by –, + and multiple of + signs, respectively. Each test was replicated thrice.

Source of Information: Journal of Pharmacognosy and Phytochemistry 2016; 5(4): 100-103

Article Link (Online Journal):

Funding Source:

Budget:

Total Budget (Tk.) :

Achievement/Findings:

The phytochemical screening of the medicinal plants showed the presence of various secondary metabolites which is the primary confirmation of anticancer plants. This increased the prospect for the efficient therapeutic principles of cancer treatment as most of the anticancer drugs are secondary metabolites in nature. So, further bioassay guided screening is necessary to isolate and identify the anticancer drug principals of these plants which may also be useful against other diseases.

Knowledge Management: Journal