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Study the Efficacy of Vaccine Against the Newcastle Disease (nd) in Layer Chicken

Md. Shofiqul Islam
Tamim Agro Industries Ltd, Rampura, Dhaka-1219, Bangladesh

Md. Hemayatul Islam
Department of Veterinary and Animal Sciences, University of Rajshahi, Rajshahi-6205, Bangladesh

Md. Jalal Uddin Sarder
Tamim Agro Industries Ltd, Rampura, Dhaka-1219, Bangladesh

Soniya Akter Nishi
Tamim Agro Industries Ltd, Rampura, Dhaka-1219, Bangladesh

Md. Shofinur Rahaman
Youth Training Center, Dept. of Youth Development, Naogaon, Bangladesh

Md. Atiar Rahman
Pharmatec Bangladesh, Abdul Hamid Road, Pabna, Bangladesh

Shyla Sharmin
Department of Livestock Services, Dhaka, Bangladesh

Abstract/ Executive Summary:

Context: Vaccination has been reported as the only safeguard against endemic ND. Aim: The aim of the present study was to evaluate the efficacy of vaccine against the Newcastle (ND) in layer chicken. Materials and methods: A serological examination was to measure the efficacy of antibodies of Newcastle disease virus in layer poultry birds. It was carried out at Rajshahi and Pabna Districts of Bangladesh. The serum samples were collected from different commercial layer farms from the period of July, 2013 to June, 2016. Samples were divided into several groups according to their influencing factors age, breed, color, farming system and atmospheric temperature of layer. Haemagglutination inhibition (HI) test was performed to determine the serum antibodies against ND virus. Results: The average antibody titre (6.70±0.02) of Newcastle disease was recorded by using various vaccines. Significantly (P<0.05) higher antibody titre was observed in Bovans White strain (6.79±0.03) and lowest in Novogen white strain (6.43±0.04). The age and atmospheric temperature had significant effect (P<0.05) on antibody titre of ND, but no significant (P>0.05) effect among the color and farming system. . The highest to lowest titer value was 6.85±0.32, 6.64±0.04 and 6.56±0.07 against the housing system of good, medium and poor respectively. Highest performance were found at temperature 20° to < 28°c (6.79±0.03) and highest to lowest are above 28°c (6.71±0.04) lowest(<20°c). Conclusion: Finally, RDV which manufactured by Department of Livestock Services was found best efficacy against ND was suitable for the protection ND in Bangladesh.

Keywords: Newcastle, Vaccine, Management, Vaccine titre

Location: Rajshahi and Pabna District, Bangladesh

Start Date: 00-07-2013

End Date: 00-06-2016

Program Area: Animal Health and Management

Commodity: Chicken, Vaccine

Objectives:

To evaluate the level of antibodies titre against Newcastle and in layer chicken by various Newcastle vaccines that were evaluated with age, breed and color of chicken, farming system and atmospheric temperatures was successfully achieved.

Methodology:

The present study was conducted in Rajshahi and Pabna District. Information for the studies was collected from the farmers for the period of July, 2013 to June, 2016. In a closed questionnaire survey, serum samples used in this study were collected randomly selected, apparently healthy layer chicken breeds from two districts of Bangladesh. Sample size determination: The formula of Cannon & Roe (1982) was used in determining the sample size. This was done with an assumption that the seroprevalence of ND in the country was 25 % with 95 % probability of detecting at least one infected chicken. Two districts from 20 Upazila were 4300 sampled were collected in this study from the wing vein of each bird. The blood was allowed to clot at room temperature after which sera was separated and stored at -20^oC until needed for laboratory analysis. In total of 400 layer farms was considered for Newcastle diseases vaccine titer investigation. To calculate the level of antibodies titers against ND with RDV, Avinew, Nobilis ND Lasota and Cevac New in layer chicken that was evaluated with breed, age, color, housing system and atmospheric temperature of farms. HI test was done according to the procedure of OIE (2005), briefly, two fold serial dilution of 25μl serum was made with PBS in V-bottomed microtiter plates (Nunc) up to 10th well. The positive percentage for this group was 100%. HI antibody titer varied from 1:8 to 1:128 with GMT of 15.85. Birds of this group were having higher antibody levels than the previous two groups and showed relatively decreased susceptibility to clinical infection. For the study 4 types of vaccine were included such as RDV, Livestock Research Institute, DLS, Dhaka, Bangladesh; Nobilis ND Lasota, Intervet Netherland B.V; Avinew® ND, VG/GA antigen lentogenic strain, Merial France, imported by Advance Animal Science Co. Ltd. Dhaka, Bangladesh and Cevac New L, France, imported by ACI Animal health, Dhaka, Bangladesh at dose rate of one drop eye drop or drinking water or ml intramuscularly 35-40 day’s interval. Statistical analysis: The data were analyzed by using SPSS programmed and comparison the values by DMRT according.

Source of Information: Bangladesh livestock journal. 2018. 1: 40-43, ISSN 2409-7691

Article Link (Online Journal):

Funding Source:

1.

Budget:

Total Budget (Tk.) :

Achievement/Findings:

The average antibody titer was recorded 6.70±0.02 using different types of ND vaccines. The Ranikhet disease Vaccine (RDV) which made by government was found the best protection against the ND than other vaccines. The Hyline white strain and white color chicken were recorded higher antibody titer then other groups. The highest antibody titer was found in age group of 5 to < 18 weeks. The good housing system and 20 to < 28 ? C temperature were suitable for production of antibody of ND.

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