Experimental site: This experiment was conducted at the Bangladesh Institute of Nuclear Agriculture (BINA) research field, located at the Mymensingh district of Bangladesh, geographically at 24.75° N and 85.50° E above 18 m sea level. The study period was June-November 2015. The edaphic and climatic condition: The experiment site was situated on the Old Brahmaputra Floodplain of predominantly dark grey non-calcareous alluvium soils under the Sonatala series. It was on mediumhigh land of silty loam texture with 41.35, 48.25, and 10.40% of sand, silt, and clay, respectively. The soil pH was 6.20 having OM and N of 1.56 and 0.09%, respectively. The amount of S, P, and K were 6.29, 13.0, and 0.034 mg kg-1, respectively. The experimental area belongs to the sub-tropical climate. It is characterized by high temperature, high humidity, and heavy monsoon rainfall with the occasional gusty wind in April-September and low precipitation with moderately low-temperature October-March. The maximum temperature varies from 32.3-33.5 during April-June, while January was the coldest month. About 95% of rainfall was received during April-September. The rest of the rainfall was very unevenly distributed and most uncertain. Experimental design and treatments: Rice cv. BINA Dhan-4 was grown under six combinations of manures and fertilizers i. Check, ii. Recommended Fertilizer Dose (RFD), iii. 75% RFD + one-ton pressmud (PM), iv. 75% RFD + two-tons PM, v. 75% RFD + one-ton tobacco dust (TD), and vi. 75% of RFD + two-tons TD. Treatments were laid out in a randomized complete block design replicated three times. The experimental field was divided into three blocks. Each block was again divided into six plots, including 18 plots. The size of the unit plot was 4 m × 5 m. Land preparation: The land was prepared using a two-wheel tractor (2WT) by four plowings and cross plowing followed by sun-drying for two days. Then inundation and laddering. The field was cleared by removing weeds, stubbles, and crop residues. Fertilizer and manure application The N, P, K, and S were applied in the form of urea, triple superphosphate (TSP), muriate of potash (MoP), and gypsum, respectively. The full dose of each of TSP, MoP, gypsum, and one-third of urea was applied at the time of final land preparation. The rest amount of the urea was used in two equal splits at 30 and 60 days after transplanting (DAT). The tobacco dust and pressmud were incorporated in the plots as per treatments seven days before transplanting. The recommended fertilizer rate of N, P, K, and S was 65, 8, 25, and 8 kg ha-1 , respectively, while their 75% was used at 48.75, 6,18.75, and 6 kg ha-1 , respectively. Seedling raising and transplanting: A common procedure was followed in raising seedlings in the seedbed. For this purpose, a previously prepared, well-leveled land was selected. The nursery bed was prepared by puddling the wetland with repeated plowing followed by laddering. The seeds were dipped in water for about 21 hours, and thereafter these were taken out and kept in the shed in two moist gunny bags for sprouting. After three days, sprouted seeds were broadcasted on the prepared seedling nursery. Crop harvesting, nutrient uptake, and soil analysis At maturity, the crop was harvested, and agronomic data viz. plant height, tillers m-2, panicle length (cm), grains panicle-1, 1000-grain weight (g), and grain, and straw yields (t ha-1) were recorded. Grain yield was expressed at 14% moisture basis and straw yield at sundry basis, drying was done for a period until a constant weight was obtained. Percent yields increase over control (YOC) was calculated as described below. YOC (%) = {(YT - YC) / (YC)} x 100. Where YT and YC represent the yield in treatment and control, respectively. The gross benefit was calculated by deducting the variable cost from the gross return. The benefit-cost ratio (BCR) was calculated by using the formula as follows: BCR = (Gross Return) / (The total cost of production). The dried grain and straw samples were ground for the analysis of N, P, K, and S contents following standard methods (H2SO4 digestion for N and HNO3-HClO4 digestion for P, K, and S). Nutrient uptake by the grain and straw was calculated by multiplying their percent concentration with the corresponding yield. Composite soil samples were collected from every plot and prepared for chemical analysis. Statistical analysis: Data were subjected to analysis of variance. Treatment means were separated by the Duncans' Multiple Range Test at P<0.05. The statistical package program MSTAT-C was used to analyze all data.