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Research Detail

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Dr.A.K.M. Mohiuddin
Professor
Faculty of Life Science, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh

Maidul Islam
Lecturer
Department of Biochemistry and Biotehnology, Khwaja Yunus Ali University, Enayetpur, Sirajgonj-6751, Bangladesh

Shahin Mahmud
Faculty of Life Science, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh

Md. Aminul Islam Apu
Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh.

Joyanta Halder
Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh.

Md. Sadek Hosen Khoka
Faculty of Life Science, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh

Hasibul Hoque Rakib
Faculty of Life Science, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh

Binita Shome
Faculty of Life Science, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh

Md. Shariful Islam*
Faculty of Life Science, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh

In the new era of Biotechnology, modern medicine system is so so advanced but still now, some of the common diseases are successfully and easily treated with the ayurvedic or herbal medicinal treatment; which is a major and important part of the modern treatment system. Terminalia chebula is termed the 'king of medicine' in the ayurvedic land of science (medicinal harbal science), due to its huge quantity of pharmacological, biological and phytochemical rich constituents. HORTOKI is the Bengali term of this plant. The demand for herbal therapeutics is now increasing in modern biological science gradually worldwide. Terminalia chebula is one of the most commonly used plants in traditional systems of medicine in Bangladesh. It is a mild, safe and effective laxative in traditional medicine. It is reported to contain various pharmacological activities including antioxidant, antidiabetic, antibacterial, antiviral, antifungal, anticancerous, antiulcer, antimutagenic, wound healing, immunomodulatory, cardioprotective effect, antiaging, cytoprotective and hepatoprotective activities. It has been reported to contain various biochemical constituents including tannins, chebulinic acid, ellagic acid, gallic acid, punicalagin and flavonoids. Several pharmacological investigations for different biological activities of Terminalia chebula in various in vivo and in vitro test models have been carried out based on the presence of biochemical ingredients and pharmacological findings. This updated review gives a bird’ eye view on the biological and ethnopharmacological properties of various phytoconstituents and the biological uses of Terminalia chebula (HORTOKI) to enrich our knowledge about this plant. 

  Terminalia chebula, Pharmacological studies, Phytoconstituents, King of medicine, Chebulinic acid, Antimutagenic, Antidiabetic.
  In Bangladesh
  
  
  Development of Host and Medicinal Plants
  Medicinal Plants

 It is a well-known fact that the demand for the ayurvedic drug treatment of various ailments is increasing day by day and plant drugs from the ayurvedic system are being explored more, not only in Bangladesh but also globally around the world. As a result, many research studies and findings are being undertaken and there is a need for an update and to put them together. That’s why in this article an attempt has taken to recapitulate available pharmacological, phytochemical and biological studies for Terminalia chebula. This gives a wide knowledge about the ayurvedic plants and their importance in personal healthcare and hygiene products. 

2.1 Botanical Description The botanical description of terminalia chebula contains, it is a medium-sized, deciduous tree up to 25m tall, 60-80cm in diameter, crown rounded, spreading branches, dark brown branches with woody scales; leaves are thin- coriaceous, ovate, rounded at base, petiole up to 2cm long, 5-7cm long spikes flowers, 5 lobed calyx, absent corolla, 10 stamens, celled-1, ellipsoid drupe fruit, yellow to orange-brown when ripe.

2.2 Phytochemistry of Terminalia chebula Biologically active phytochemical constituents are includes chebulic acid, chebulinic acid[26], ellagic acid, gallic acid, chebulagic acid[28],1,6 di-O-galloyl-β-D-glucose, 3,4,6 tri-O-galloyl-β-D-glucose, 2,3,4,6 tetra-O-galloyl-β-D-glucose, 1,2,3,4,6 penta-O galloyl-βD-glucose, ellagitanin contains punacalagin, casurarinin, corilagin, terchebulin, chebulanin, neochebulinic acid, chebulagic acid and phenolic compounds. High phenolic content, specially hydrolyzable tannins, anthraquinone, flavonol, carbohydrates, glucose and sorbitol, with pharmacological studies from reverse phase chromatography there are some valuable active phytoconstituents has been reported including gallic acid, methyl gallate, ethyl gallate, chebulagic acid, tetra-O-galloyl-β-D-glucose, ellagic acid, chebulinic acid and penta-O galloyl-β-D-glucose. It also contains nutrients such as vitamin C, protein, amino acids and minerals.

2.3 pharmacological and biological uses Terminalia chebula is called "The king of medicines" because of its high content of alkaloids, secondary metabolites, flavonoids and the astonishing power of healing with a wide range of biological and pharmacological uses. Important biological uses by this plant includes antibacterial, antifungal, antiviral, antimutagenic, adaptogenic, anti-anaphylacatic, hypocholesterolemic, gastrointestinal motility improving, anti-ulcerogenic, hepatoprotective, cardioprotective, radioprotective, antidiabetic and retinoprotective, antispasmodic, wound healing, purgative, immunomodulatory and chemopreventive activities. Gallic acid acts as an anti-inflammatory response binding with receptors. It is used as a blood purifier.[36] Several pharmacological investigations for different biological activities of Terminalia chebula in various in vivo and in vitro test models have been carried out based on the presence of chemical ingredients. 

 

  World Journal of Pharmaceutical Research Vol 4, Issue 05, 2015.
  
Funding Source:
1.   Budget:  
  

We are now living in a modern era as a result medical science are developing day by day inspite of this a large segment of the world population still now depends on the plants origin medicine. Terminalia chebula is one of the world most valuable ayurvedic plants having a wide variety of pharmacological and medical activities. From the ancient time, plants have been widely used as curative agents for variety of ailments. Terminalia chebula serves as a great source of a variety of biologically active phytoconstituents as for example chebulic acid, chebulinic acid, gallic acid, chebulagic acid and other related compounds that compounds are result to antimicrobial, antitoxidant, antihyperglycemic, anticancer, and protective effects on various vital organs those are includes nervous, heart, kidney, liver. To treat a large number variety of health problems Terminalia chebula plant is generally used. By showing the biodiversity of both nutritional as well as medicinal components Terminalia chebula is known as the root of medicine. Day by day the investigation on medicinal plants are rising so fast as a result herbal products are becoming safe and effective to the people. We wish this work will help to create awareness about medicinal plant research and their future possibility. 

  Journal
  


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