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Research Detail

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Dr. Md Khorshed Alam*
Hakim Said Eastern Medical College and Hospital, Dhaka, Bangladesh

Dr. Md Obydul Hoq
Hakim Said Eastern Medical College and Hospital, Dhaka, Bangladesh

Dr. Md Shahab Uddin
Hakim Said Eastern Medical College and Hospital, Dhaka, Bangladesh

Garlic Allium sativum the Liliaceae family, is among the oldest of all cultivated plants. It has been used as a medicinal agent for thousands of years. Garlic is one of the most important bulb vegetables, which is used as spice and flavoring agent for foods Garlic adds to taste of foods as well as it helps to make them digestible. Garlic contains different useful minerals, vitamins and many other substances used for health of human beings. It is rich in sugar, protein, fat, calcium, potassium, phosphorous, sulfur, iodine fiber and silicon in addition to vitamins. It possesses high nutritive value. Furthermore, garlic has pharmaceutical effects and used to cure a vast conditions including blood pressure and cholesterol, cancer, hepatoprotective, anthelmintics, anti-inflammatory, antioxidant, antifungal and wound healing, asthma, arthritis, sciatica, lumbago, backache, bronchitis, chronic fever, tuberculosis, rhinitis, malaria, obstinate skin disease including leprosy, leucoderma, discoloration of the skin and itches, indigestion, colic pain, enlargement of spleen, piles, fistula, fracture of bone, gout, urinary diseases, diabetes, kidney stone, anemia, jaundice, epilepsy, cataract and night blindness. Garlic products are used as sources of medicine in many ways in human beings in their day today life. As a result, researchers from various disciplines are now directing their efforts towards discovering the medicinal values of garlic on human health. The main interest of researchers in the medicinal values of garlic is its broad-spectrum therapeutic effect with minimal toxicity.

  Garlic, Medicinal plant, Allicin, Antihypertensive, Antidiabetic. Antiatherosclerosis
  In Bangladesh
  
  
  Development of Host and Medicinal Plants
  Medicinal Plants

 A component of garlic, S-methylcysteine sulfoxide (SMCS), has been shown to reduce both blood cholesterol and the severity of atherosclerosis (Sainani et al. 1979). Garlic has protective effects against stroke, coronary thrombosis, atherosclerosis, platelet aggregation, as well as infections and vascular disorders. However, we must note that there is considerable controversy concerning the cholesterol lowering effects of garlic and a number of studies have reported that some garlic preparations do not lower serum cholesterol. The fibrinolytic activity of garlic in both man and experimental animals has been reported.

Many claims of an antibiotic action, a hypoglycemic effect, antitumor, antioxidant and antithrombotic properties have also been attributed to the garlic extracts (Alnaqeeb et al. 1992).

2. Botanical Description Other members of the onion genus, Allium, include A. cepa (onion), A. schoenoprasum (chives), A. ascalonicum (shallots), and A. porrum (leeks). Allium sativum is further divided into two subspecies, A. sativum var. sativum, also known as softneck garlic, and Allium sativum var. ophioscorodon, also known as hardneck garlic. Both varieties are composed of an underground bulb made up of cloves, which are prophylls enclosed by dry membranous skins and held together by a basal plate. The variations differ in that hard neck garlic’s bulb is composed of six to eleven cloves, circled around a centralized woody stalk. This variety of garlic has a scape that curls at the top, but it is generally removed after it curls one to three times. This is because if it continues to grow, less energy can be utilized towards the bulb. Eventually, the scape would give rise to bulbils, containing miniature cloves. The bulbils are occasionally accompanied by white or light purple flowers, although these are sterile. Softneck garlic does not have a flowering top and contains up to twenty-four cloves per bulb. The stem is central and soft, hence the name, and the cloves are layered with larger ones on the outside. Allium sativum is the more common variation, many studies involving garlic do not specify which subspecies is used, but chemical and biological action are assumed to be similar. Allium sativum is sterile and hence is grown asexually from cloves, not requiring a pollinator. It grows best in mild climates, through hardneck varieties are better adapted to colder environments. Allium sativum is a perennial species, as are most members of the genus. Garlic is composed of very strong organosulfur compounds that serve as secondary metabolites as described in the section entitled chemistry and pharmacology. These compounds are responsible for the very pungent smell and taste of raw garlic and act as defenses against predators (Block 2010).

2.1 Bulb Rounded, composed of up to about 15 smaller bulblets known as cloves. Cloves and bulbs are covered by a whitish or pinkish tunic (papery coat).

2.2 Leaves Four to twelve long, sword-shaped leaves attached to an underground stem.

2.3 Flowers Borne in a dense, spherical cluster on a spike (flower stalk) up to 25 cm long. The young flower head is enclosed in a long-beaked pair of enclosing bracts, which become papery and split to reveal the flowers. Individual flower stalks arise from a common point. Flowers are greenish-white or pinkish with six perianth segments (sepals and petals) about 3 mm long. Bulbils (asexual propagules), which resemble tiny cloves, are often interspersed among the flowers.

2.4 Fruits Flowers usually abort before developing to a stage at which fertilization could take place. 2.5 Seeds Not usually produced in the wild but have been produced under laboratory conditions. With a black coat, similar to onion seeds, but approximately half the size.

  Journal of Medicinal Plants Studies 2016; 4(6): 72-79
  
Funding Source:
1.   Budget:  
  

Garlic, from crushed to capsules, is consumed throughout the world. This abstract demonstrates by documented studies the benefits of garlic for its anti-microbial, antioxidant and anti-inflammatory potential. It has been used to treat cardiovascular diseases, including atherosclerosis, strokes, hypertension, thrombosis and hyperlipidemias, as well as uses in Alzheimer’s, diabetes, and cancer. Most impressive and unique are its use and safety in children. Although some studies show medicinal benefits of garlic, there are others which do not. Clearly more studies are needed. Fresh and powdered garlic are popular for food seasoning and should continue to be used. Today, with the ever-growing resistant organisms, garlic, taken alone or with other herbal antibiotics such as grape seed extract or ginger, remains a powerful antimicrobial agent. Clearly more studies are needed to refine the use and improve the efficacy of this important plant medicine. 

  Journal
  


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