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Anti-inflammatory Activity of Medicinal Plants Native to Bangladesh: a Review

Apurba Sarker Apu
Department of Pharmacy, East West University, Dhaka-1212, Bangladesh.

Shakhawat Hossan Bhuyan
Department of Pharmacy, East West University, Dhaka-1212, Bangladesh.

Shamina Saiyara Prova
Department of Pharmacy, East West University, Dhaka-1212, Bangladesh.

Md. Abdul Muhit
Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

Abstract/ Executive Summary:

Inflammation is characterized by redness, pain and swelling. Anti-inflammatory drugs are agents that reduce inflammation. It has been found that conventional synthetic NSAIDs accelerate damage and erosion of joint cartilage, advancing the osteoarthritis process. These NSAIDs are also known to cause liver and kidney damage with long-term use. Experimental research have shown that the use of proven natural anti-inflammatory herbal agents have not been shown to cause erosion injury to the intestinal tract, acceleration of cartilage destruction or production of liver and kidney toxicities. This enables practitioners to use these substances in a safe and responsible way. In this overview the medicinal plants reported to have antiinflammatory activity available in Bangladesh are summarized to assess the research advancements.

Keywords: Anti-inflammatory, Inflammation, Bangladesh, NSAID, Medicinal plants, Pain

Location: In Bangladesh

Start Date:

End Date:

Program Area: Development of Host and Medicinal Plants

Commodity: Medicinal Plants

Objectives:

In particular many people have a short course of an anti-inflammatory for all sorts of painful conditions. However, side-effects, and also occasionally very severe possible adverse effects, can occur. There are a number of anti-inflammatory herbs that could help to achieve similar results without the harmful effect.

Methodology:

DESCRIPTION Despite the progresses in modern medicine, it has been reported that more than 70% of the developing world's population still depends on complementary and alternative systems of medicine, otherwise known as traditional medicine (Shaikh et al., 2005). Some herbs possess anti-inflammatory properties and have the ability to reduce both internal and external swelling and inflammation. Herbal drugs have gained importance and popularity in recent years because of their safety, efficacy and cost-effectiveness. In Bangladesh, there are several indigenous medicinal plants available that have anti-inflammatory capabilities.

Source of Information: Journal of Applied Pharmaceutical Science 02 (02); 2012: 07-10

Article Link (Online Journal):

Funding Source:

Budget:

Total Budget (Tk.) :

Achievement/Findings:

The advancement of allopathic medication shifted scientific and general people’s interest from conventional medicinal preparations. However, in recent years, a significant paradigm change has taken place. The attraction has re-focused in traditional medicine, simply because of the higher cost of modern drugs, time and expenditure which is essential to bring a drug to market after proper clinical tests, severe side-effects of a variety of modern drugs, and drug-resistance developing in both microorganisms and parasites. So, researchers are currently taking an active interest in traditional medicinal preparations of native peoples, which are plant-based. In recent years researcher are working on anti-inflammatory plants. Inflammatory diseases are common in the aging society of developed and developing countries; yet, the drugs used to combat inflammatory diseases like rheumatoid arthritis often have serious side-effects. Several leads from plant sources, like curcumin, resveratrol, baicalein, boswellic acid, betulinic acid, ursolic acid and oleanolic acid are now studied as possible drugs for the future against inflammatory (Gautam et al., 2009). This review will help the recent and future researchers in their research work as they could select the anti-inflammatory medicinal plants from which they can isolate active constituents by using various separation techniques. These types of research works may unveil some new molecules which help us to fight against inflammatory disorders.

Most of the researchers concluded their study by mentioning that the anti-inflammatory activity may be due to inhibition of the enzyme cyclooxygenase leading to inhibition of prostaglandin synthesis. But more extensive study could be conducted to determine exact mechanism(s) of action.

Knowledge Management: Journal