Agricultural Research Management Information System

  • Home
  • Research Summary
    • All
    • Government Organization
      • Agriculture Training Institute, Ishwardi, Pabna
      • Bangabandhu academy for poverty alleviation and rural development (BAPARD)
      • Bangabandhu Sheikh Mujibur Rahman Science & Technology University
      • Bangladesh Bureau of Statistics
      • Bangladesh Institute of Health Sciences
      • Bangladesh Institute of Tropical & Infections Diseases (BITID)
      • Bangladesh Meteorological Department
      • Bangladesh National Herbarium
      • Bangladesh Space Research and Remote Sensing Organization
      • Bangladesh Technical Educational Board
      • Barind Multipurpose Development Authority
      • Central Cattle Breeding Station
      • Department of Agriculture Extension
      • Department of Fisheries
      • Department of Livestock Services
      • Department of Youth Development
      • Dhaka Medical College
      • Geological Survey of Bangladesh
      • Institute of Epidemiology, Disease Control & Research
      • Jatiya Kabi Kazi Nazrul Islam University
      • Khulna Govt. Women College
      • Livestock Training Institute
      • Local Government Engineering Department
      • Ministry of Agriculture
      • Ministry of Environment and forest
      • Ministry of Fisheries and Livestock
      • Ministry of Labour & Employement
      • Ministry of Land
      • Ministry of Public Administration
      • Ministry of Textiles and Jute
      • Ministry of Water Resources
      • Ministry of Youth and Sports
      • National Agricultural Training Academy
      • National institute of preventive and social medicine
      • National Mushroom Development and Extension Centre
      • Pabna University of Science and Technology
      • Seed Certification Agency
      • Shaheed Suhrawardy Medical College
      • Sheikh Hasina University
      • University Grants Commission
      • Youth Training Centre
    • Autonomous/Semi-gov Org
      • Bangladesh Academy for Rural Development
      • Bangladesh Agricultural Development Corporation
      • Bangladesh Atomic Energy Commission
      • Bangladesh Council of Scientific and Industrial Research
      • Bangladesh Fisheries Development Corporation
      • Bangladesh Institute of Development Studies
      • Bangladesh Institute of Management
      • Bangladesh Milk Producers Cooperative Union Limited
      • Bangladesh Water Development Board
      • BIRDEM
      • Center for Environmental and Geographic Information Services
      • Hortex Foundation
      • Institute of Water Modeling
      • National Institute of Biotechnology
      • River Research Institute
      • Rural Development Academy
    • NARS
      • Bangladesh Agricultural Research Council
      • Bangladesh Agricultural Research Institute
      • Bangladesh Fisheries Research Institute
      • Bangladesh Forest Research Institute
      • Bangladesh Institute of Nuclear Agriculture
      • Bangladesh Jute Research Institute
      • Bangladesh Livestock Research Institute
      • Bangladesh Rice Research Institute
      • Bangladesh Sericulture Research and Training Institute
      • Bangladesh Sugarcrop Research Institute
      • Bangladesh Tea Research Institute
      • Bangladesh Wheat and Maize Research Institute
      • Cotton Development Board
      • Soil Resource Development Institute
    • Public University
      • Ahsanullah University of Science and Technology
      • Bangabandhu Sheikh Mujibur Rahman Agricultural University
      • Bangamata Sheikh Fojilatunnesa Mujib Science and Technology University
      • Bangladesh Agricultural University
      • Bangladesh Open University
      • Bangladesh University of Engineering and Technology
      • Bangladesh University of Professionals
      • Bangladesh University of Textiles
      • Barisal Government Veterinary College
      • Begum Rokeya University
      • Chittagong University of Engineering and Technology
      • Chittagong Veterinary and Animal Science University
      • Comilla University
      • Dhaka University of Engineering & Technology
      • Dinajpur Government Veterinary College, Dinajpur
      • Gono Bishwabidyalay
      • Hajee Mohammad Danesh Science and Technology University
      • Islamic University, Kushtia
      • Jagannath University
      • Jahangirnagar University
      • Jessore University of Science and Technology
      • Jhenaidha Government Veterinary College
      • Khulna Agricultural University
      • Khulna University
      • Khulna University of Engineering & Technology
      • Mawlana Bhashani Science and Technology University
      • Millitary Institute of Science and Technology
      • National University
      • Noakhali Science and Technology University
      • Patuakhali Science and Technology University
      • Rajshahi University of Engineering and Technology
      • Shahjalal University of Science & Technology
      • Sher-e-Bangla Agricultural University
      • Sylhet Agricultural University
      • Sylhet Government Veterinary College
      • University of Barisal
      • University of Chittagong
      • University of Dhaka
      • University of Rajshahi
    • Private University
      • Asian University of Bangladesh
      • Atish Dipankar University of Science and Technology
      • BGC Trust University Bangladesh
      • BGMEA University of Fashion & Technology (BUFT)
      • BRAC University
      • City University
      • Daffodil International University
      • East West University
      • Exim Bank Agricultural University
      • Gana Bishwabiddalaya
      • Hamdard University
      • Independent University, Bangladesh
      • International Islamic University Chittagong
      • International University of Business Agriculture and Technology
      • Islamic University of Technology
      • Leading University, Sylhet
      • North South University
      • Premier University
      • Primeasia University
      • Private University
      • SOAS, University of London
      • Southeast University
      • Stamford University
      • State University of Bangladesh
      • The Millenium University
      • University of Asia Pacific
      • University of Development Alternative
      • University of Information Technology and Sciences
      • University of Liberal Arts Bangladesh
      • University of Science and Technology, Chittagong
      • World University
    • INGO/IO/NGO/Private Org
      • ACI Limited
      • Agricultural Advisory Society (AAS)
      • Apex Organic Industries Limited
      • Arannayk Foundation
      • Bangladesh Academy of Sciences
      • Bangladesh Centre for Advanced Studies
      • Bangladesh Institute of Social Research
      • Bangladesh Science Foundation
      • Bangladesh Unnayan Parishad
      • BAPA
      • BRAC
      • CARE Bangladesh
      • CARITAS
      • Centre for Environmental Geographical Information System
      • Centre for Policy Dialogue (CPD)
      • Creative Conservation Alliance
      • Dhaka Ahsania Mission
      • Dwip Unnayan Sangstha
      • EMBASSY OF DENMARK, BANGLADESH
      • Energypac Limited Bangladesh
      • FAO- Bangladesh
      • FIVDB
      • ICDDRB, Mohakhali, Dhaka-1212
      • iDE Bangladesh
      • Innovision Consulting Private Ltd.
      • International Center for Climate Change and Development
      • International Centre for Integrated Mountain Development
      • International Development Research Centre
      • International Fertilizer Development Center, Bangladesh
      • International Food Policy Research Institute
      • International Maize and Wheat Improvement Centre
      • International Potato Center
      • IRRI- Bangladesh
      • IRRI-Philippines
      • Ispahani Agro LTD
      • IUCN, Bangladesh
      • Krishi Gobeshina Foundation
      • Lal Teer
      • Mennonite Central Committee
      • Metal (Pvt.) Ltd
      • Modern Herbal Group
      • Palli Karma-Sahayak Foundation
      • Practical Action Bangladesh
      • Proshika
      • RDRS Bangladesh
      • RIRI-Philippines
      • Rothamsted Research
      • SAARC Agricultural Centre
      • SAARC Meteorological Research Centre
      • Social Upliftment Society
      • South Asia Enterprise Development Facility
      • Square Pharmaceuticals Ltd.
      • Supreme Seed
      • Transparency International Bangladesh
      • Unnayan Onneshan
      • USAID
      • Water Resources Planning Organization
      • Winrock International
      • World Bank
      • World Food Program
      • World Vegetable Center
      • WorldFish Centre, Bangladesh
    • Foreign University
      • Asian Institute of Technology
      • Auckland University of Technology
      • Australian National University
      • Bidhan Chandra Krishi Viswavidyalaya
      • BOKU-University of Natural Resources and Applied Life Sciences
      • Cranfield University
      • Curtin University
      • Foreign University/ Institute
      • Hiroshima University
      • Hokkaido University
      • Huazhong Agricultural University
      • International Islamic University, Malaysia
      • Kagawa University
      • Kangwon National University
      • Kochi University
      • Kyoto University
      • Kyushu University
      • Ladoke Akintola University of Technology
      • Murdoch University
      • Nagoya University
      • NOAA-CREST, CCNY
      • Royal Veterinary and Agricultural University
      • San Diego State University
      • Shinshu University
      • Tottori University
      • United Nations University
      • University Malaysia Kelantan
      • University Malaysia Pahang
      • University Nova de Lisboa
      • University of Alberta
      • University of Bremen
      • University of Bremen
      • University of Calgary
      • University of california
      • University of Greenwich
      • University of Hamburg, Hamburg
      • University of Hannover
      • University of Hawaii
      • University of Helsinki, Finland
      • University of Kalyani
      • University of Leeds
      • University of Liverpool
      • University of Malaya
      • University of Milan
      • University of New England
      • University of Philippines
      • University of Plymouth
      • University of Queensland
      • University of Reading
      • University of Southampton
      • University of Texas
      • University of the Punjab
      • University of Tokyo
      • University of Toronto
      • University of Wales
      • University of Washington
      • University of Wollongong
      • University Putra Malaysia
      • University Sains Malaysia
  • Search
    • Search by Keyword
    • Search by Organization
    • Search by Program Area
    • Search by Commodity/Non-commodity
    • Search by Funding Source
    • Search by Researcher
    • Custom Search
    • On-going Research
  • About Us
    • ARMIS
    • Brochure
  • Contact Us
    • BARC Personnel
    • ARMIS Personnel
    • Feedback
  • Report
    • All
    • By Organization
      • Bangladesh Agricultural Research Council
      • Bangladesh Agricultural Research Institute
      • Bangladesh Fisheries Research Institute
      • Bangladesh Forest Research Institute
      • Bangladesh Institute of Nuclear Agriculture
      • Bangladesh Jute Research Institute
      • Bangladesh Livestock Research Institute
      • Bangladesh Rice Research Institute
      • Bangladesh Sericulture Research and Training Institute
      • Bangladesh Sugarcrop Research Institute
      • Bangladesh Tea Research Institute
      • Bangladesh Wheat and Maize Research Institute
      • Cotton Development Board
      • Soil Resource Development Institute
    • Research Trend Analysis
  • User Request
  • Data Input
  • Help
    • Operation Manual
      • PDF
      • Video
    • Program Area & Commodity
  • We have reached 37600 number of research entries at this moment.
    • Logout

Research Detail

  1. Home
  2. Research
  3. Detail
Sheikh Rashel Ahmed
Department of Plant and Environmental Biotechnology, Faculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet 3100, Bangladesh

Muhammad Fazle Rabbee
Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Korea

Anindita Roy
Department of Plant and Environmental Biotechnology, Faculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet 3100, Bangladesh

Rocky Chowdhury
School of Medicine, Deakin University, 75 Pigdons Rd, Waurn Ponds, Melbourne, VIC 3216, Australia

Anik Banik
Department of Plant and Environmental Biotechnology, Faculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet 3100, Bangladesh

Khadizatul Kubra
Department of Biotechnology and Genetic Engineering, Faculty of Science, Noakhali Science and Technology University, Noakhali 3814, Bangladesh

Mohammed Mehadi Hassan Chowdhury*
Department of Microbiology, Faculty of Science, Noakhali Science and Technology University, Noakhali 3814, Bangladesh

Kwang-Hyun Baek*
Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Korea

When functioning properly, the stomach is the center of both physical and mental satisfaction. Gastrointestinal disorders, or malfunctioning of the stomach, due to infections caused by various biological entities and physiochemical abnormalities, are now widespread, with most of the diseases being inflammatory, which, depending on the position and degree of inflammation, have different names such as peptic or gastric ulcers, irritable bowel diseases, ulcerative colitis, and so on. While many synthetic drugs, such as non-steroidal anti-inflammatory drugs, are now extensively used to treat these diseases, their harmful and long-term side effects cannot be ignored. To treat these diseases safely and successfully, different potent medicinal plants and their active components are considered game-changers. In consideration of this, the present review aimed to reveal a general and comprehensive updated overview of the anti-ulcer and anti-inflammatory activities of medicinal plants. To emphasize the efficacy of the medicinal plants, various bioactive compounds from the plant extract, their experimental animal models, and clinical trials are depicted.

  Medicinal plants; Anti-ulcer; Inflammation; Bioactive compounds; Metabolites; Therapeutic uses
  In Bangladesh
  
  
  Pest Management
  Medicinal Plants

This review focuses on supporting the therapeutic use of medicinal plants available in Bangladesh in the treatment of various inflammatory diseases of the gastrointestinal tract. Here, we have considered and reviewed the published articles using the keywords: medicinal plants, bioactive compounds, ulcers, inflammation, anti-ulcers, and anti-inflammatory diseases since 2000, from different databases like PubMed (https://pubmed.ncbi.nlm.nih.gov/) (accessed on 21 May 2021), Scopus Database (https://scopus.com) (accessed on 21 May 2021), and Google Scholar (https://scholar.google.com/) (accessed on 21 May 2021). The research findings of relevant medicinal plants, native or cultivated, in Bangladesh, were taken into consideration

2. Inflammatory Diseases and Ulcers Inflammation is a natural reaction in the defense of tissues against various injuries caused by physical stress combined with harmful chemicals or microbes. Inflammation tends to be one of the prime causes for the occurrence of various diseases such as cancer, obesity, cardiovascular disease, rheumatoid arthritis, osteoporosis, asthma, IBD, central nervous system (CNS) depression, diabetes, and Parkinson disease. Inflammation can be triggered by many stimuli including pathogens or cytokines (i.e., interleukin-6 or IL-6, tumor necrosis factor-alpha or TNF-α, neutrophils, and monocytes). These stimulating agents can be differentiated into macrophages, which are subsequently attracted to injured tissue sites by chemotaxis and intensify the inflammatory reactions to the damaged areas as well as initiate phagocytosis [25]. Inflammation can be characterized by swelling, joint pain, and redness. Inflammation leads to several chronic diseases including arthritis, autoimmune disease, coeliac disease, colitis, and asthma, which are often associated with the increased risk of development of cardiovascular diseases, diabetes, cancer, and osteoporosis [26]. Phytochemicals derived from medicinal plants can be used in the alleviation of inflammatory reactions by inhibiting different forms of enzymes e.g., lipoxygenase (LOX), cyclooxygenase (COX), phospholipase A2, and proteins (e.g., inhibition of the proinflammatory cytokines). In medical science, Crohn’s disease, and ulcerative colitis (UC) are two types of IBD that cause inflammation in the entire gastrointestinal tract and colonic mucosa, raising the risk of colon cancer as well. An ulcer is the condition of corrosion in the linings of the stomach and the duodenum. Thus, ulcers in the gastrointestinal tract are subdivided into ulcerative colitis (lower) and peptic ulcers (upper) depending on the location of the infection. Peptic ulcers, also known as gastric and duodenal ulcers, can be characterized as submucosal damage of the digestive tract caused by the disruption of the balance between the hostile factors (i.e., gastric acid, Helicobacter pylori, and anti-inflammatory drugs) and protective factors (i.e., mucus, bicarbonate, prostaglandins, and blood flow towards the mucosa). The common symptoms of peptic ulcers include a burning sensation and pain in the middle or upper stomach, bloating, heartburn, nausea or vomiting, and weight loss. Excessive consumption of alcohol, smoking, chewing tobacco, serious illness, and the intake of NSAIDs increase the risk of ulcer development. Gastric ulcers and duodenal ulcers, which are more prevalent in the Eastern and Western countries, cause morbidity and mortality worldwide, and H. pylori are considered as one of the most important factors in the development of this disease.

3. Plant Mediated Treatment of Ulcer and Inflammatory Diseases Medicinal plants are the blessings of nature that humans have been using since prehistoric times as the precursor of most drugs. The treatment of ulcers and IBD is facilitated by the intensive use of many medicinal plants. In addition, in recent years, numerous studies on plant extracts have substantially demonstrated anti-ulcer and anti-inflammatory activities in both in vitro and in vivo models. Drugs derived from medicinal plants are effective against inflammation of the digestive tract primarily in two ways, either by reducing acid and pepsin secretion or by assisting the cytoprotection via mucosal defense factors. The mode of action of these drugs differs according to their function. These medications maintain a balance between several aggressive factors (i.e., pepsin, acid, bile salts, and H. pylori) and defensive factors (i.e., cellular mucus, mucin secretion, mucosal blood flow, bicarbonate secretion, and cell turnover). For instance, the methanol extract of drumstick leaves, and flower buds inhibited aspirin-induced gastric lesion formation in rats. It has been reported that several compounds, such as cavidine, chelerythrine, quercetin, hesperidin, α-pinene, and garcinol, present in medicinal plants were used against ulcer diseases. Additionally, prominent anti-inflammatory compounds such as resveratrol, colchicine, epigallocatechin3-gallate (EGCG) capsaicin, phytosterols, saponins, and curcumin derived from plants were used to treat inflammatory diseases.

In addition to the use of traditional medicines such as NSAIDs, the use of proton pump inhibitors (e.g., pantoprazole, omeprazole, lansoprazole, and rabeprazole), histamine receptor blockers (e.g., famotidine and ranitidine), synthetic prostaglandin E1 (e.g., misoprostol), antacids (e.g., aluminum hydroxide and magnesium trisilicate combination), corticosteroids (e.g., dexamethasone), immune-suppressants, immune-modulators (e.g., azathioprine and 6-mercapto-purine), antibiotics (e.g., clarithromycin and metronidazole), and biologic agents (e.g., TNF-α) for the treatment of inflammatory diseases is in practice on a large scale and has significant adverse and undesirable side effects including gastrointestinal and hepatic toxicity, renal and cardiovascular malfunctions, and hematologic effects such as hemophilia and thrombocytopenia. As a result, the use of natural products such as plants and herbal derivatives is increasingly growing among ulcerated and inflammatory patients having minimal or no side effects as they are the products of nature. Different types of plants that are currently considered to be effective to treat ulcers and inflammatory diseases are discussed.

  Plants 2021, 10, 1348.
  https://doi.org/10.3390/plants10071348
Funding Source:
1.   Budget:  
  

There is a belief that the solutions to all health problems can be found in nature. Currently, humans are victimized by various life-threatening diseases, and in the form of medicinal plant, nature has proven its potency in preventing and curing these diseases. Between 70% and 80% of people throughout the world are solely dependent on primitive or herbal medicines. The worldwide demand for herbal medicine is great and is growing. However, the trials and experiments in this sector are very limited until recently, and this reflects our lack of knowledge about nature. All around the world, there are huge numbers of medicinal plants but the medicinal value of less than one-third of them have been discovered and identified. Still now, more comprehensive, and reliable scientific studies are needed to evaluate and ensure the safety and efficiency of medicinal plants, as well as their potential metabolites in ulcers and inflammatory disease treatment. The quality of the targeted active compounds should be tested repeatedly or batch-to-batch for ensuring reproducibility as well as uniformity of the active components. The implementation of randomized clinical trials overcoming exiting challenges like study design, selection of controls, and active ingredients standardization is urgently needed. International and local regulatory bodies should come forward to facilitate and monitor the clinical trials for achieving a breakthrough outcome.

  Journal
  


Copyright © 2025. Bangladesh Agricultural Research Council.